Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication.

Luganini, Anna; Sibille, Giulia; Mognetti, Barbara; Sainas, Stefano; Pippione, Agnese Chiara; Giorgis, Marta; Boschi, Donatella; Lolli, Marco L; Gribaudo, Giorgio

Luganini, Anna; Sibille, Giulia; Mognetti, Barbara; Sainas, Stefano; Pippione, Agnese Chiara; Giorgis, Marta; Boschi, Donatella; Lolli, Marco L; Gribaudo, Giorgio.

Afiliación

Luganini A; Department of Life Sciences and Systems Biology, 10123, Turin, Italy.
Sibille G; Department of Life Sciences and Systems Biology, 10123, Turin, Italy.
Mognetti B; Department of Life Sciences and Systems Biology, 10123, Turin, Italy.
Sainas S; Department of Sciences and Drug Technology, University of Turin, 10125, Turin, Italy.
Pippione AC; Department of Sciences and Drug Technology, University of Turin, 10125, Turin, Italy.
Giorgis M; Department of Sciences and Drug Technology, University of Turin, 10125, Turin, Italy.
Boschi D; Department of Sciences and Drug Technology, University of Turin, 10125, Turin, Italy.
Lolli ML; Department of Sciences and Drug Technology, University of Turin, 10125, Turin, Italy.
Gribaudo G; Department of Life Sciences and Systems Biology, 10123, Turin, Italy. Electronic address: giorgio.gribaudo@unito.it.

Antiviral Res ; 189: 105057, 2021 05.

Article en En | MEDLINE | ID: mdl-33716051

Asunto(s)

Antivirales/farmacología; Inhibidores Enzimáticos/farmacología; Herpes Simple/tratamiento farmacológico; Herpesvirus Humano 1/efectos de los fármacos; Herpesvirus Humano 2/efectos de los fármacos; Oxidorreductasas actuantes sobre Donantes de Grupo CH-CH/antagonistas & inhibidores; Replicación Viral/efectos de los fármacos; Aciclovir/farmacología; Animales; Línea Celular Tumoral; Chlorocebus aethiops; Replicación del ADN/efectos de los fármacos; ADN Viral/biosíntesis; Dihidroorotato Deshidrogenasa; Sinergismo Farmacológico; Quimioterapia Combinada; Regulación Viral de la Expresión Génica/efectos de los fármacos; Herpes Simple/virología; Humanos; Pirimidinas/biosíntesis; Células Vero

Palabras clave

Antiviral activity; Combination treatment; Dihydroorotate dehydrogenase; Herpes simplex virus type 1 and type 2; Salvage pathway; de novo pyrimidine biosynthesis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antivirales / Replicación Viral / Herpesvirus Humano 2 / Herpesvirus Humano 1 / Oxidorreductasas actuantes sobre Donantes de Grupo CH-CH / Inhibidores Enzimáticos / Herpes Simple Límite: Animals / Humans Idioma: En Revista: Antiviral Res Año: 2021 Tipo del documento: Article País de afiliación: Italia

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