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Serologic Cross-Reactivity of SARS-CoV-2 with Endemic and Seasonal Betacoronaviruses.
Hicks, Jennifer; Klumpp-Thomas, Carleen; Kalish, Heather; Shunmugavel, Anandakumar; Mehalko, Jennifer; Denson, John-Paul; Snead, Kelly R; Drew, Matthew; Corbett, Kizzmekia S; Graham, Barney S; Hall, Matthew D; Memoli, Matthew J; Esposito, Dominic; Sadtler, Kaitlyn.
Afiliación
  • Hicks J; Trans-NIH Shared Resource on Biomedical Engineering and Physical Science, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20894, USA.
  • Klumpp-Thomas C; Section on Immuno-Engineering, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Kalish H; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA.
  • Shunmugavel A; Trans-NIH Shared Resource on Biomedical Engineering and Physical Science, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20894, USA.
  • Mehalko J; Section on Immuno-Engineering, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Denson JP; Section on Immuno-Engineering, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Snead KR; Protein Expression Laboratory, NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.
  • Drew M; Protein Expression Laboratory, NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.
  • Corbett KS; Protein Expression Laboratory, NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.
  • Graham BS; Protein Expression Laboratory, NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.
  • Hall MD; Vaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Memoli MJ; Vaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Esposito D; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA.
  • Sadtler K; LID Clinical Studies Unit, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20894, USA.
J Clin Immunol ; 41(5): 906-913, 2021 07.
Article en En | MEDLINE | ID: mdl-33725211
ABSTRACT
In order to properly understand the spread of SARS-CoV-2 infection and development of humoral immunity, researchers have evaluated the presence of serum antibodies of people worldwide experiencing the pandemic. These studies rely on the use of recombinant proteins from the viral genome in order to identify serum antibodies that recognize SARS-CoV-2 epitopes. Here, we discuss the cross-reactivity potential of SARS-CoV-2 antibodies with the full spike proteins of four other betacoronaviruses that cause disease in humans, MERS-CoV, SARS-CoV, HCoV-OC43, and HCoV-HKU1. Using enzyme-linked immunosorbent assays (ELISAs), we detected the potential cross-reactivity of antibodies against SARS-CoV-2 towards the four other coronaviruses, with the strongest cross-recognition between SARS-CoV-2 and SARS /MERS-CoV antibodies, as expected based on sequence homology of their respective spike proteins. Further analysis of cross-reactivity could provide informative data that could lead to intelligently designed pan-coronavirus therapeutics or vaccines.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Betacoronavirus / SARS-CoV-2 Límite: Adolescent / Adult / Humans / Middle aged Idioma: En Revista: J Clin Immunol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Betacoronavirus / SARS-CoV-2 Límite: Adolescent / Adult / Humans / Middle aged Idioma: En Revista: J Clin Immunol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos