[Dupilumab has an additional benefit in treatment of chronic rhinosinusitis with nasal polyps]. / Dupilumab besitzt einen Zusatznutzen für die Behandlung der chronischen Rhinosinusitis mit Nasenpolypen.
HNO
; 69(11): 868-877, 2021 Nov.
Article
en De
| MEDLINE
| ID: mdl-33738558
ABSTRACT
BACKGROUND:
For patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP) which cannot be controlled by continuous therapy with intranasal corticosteroids (INCS) and systemic corticosteroids and/or surgical treatment, there were no approved curative options for a long time. For CRSwNP treatment with T2-addressing biologics is possible. On October 24, 2019, the European Commission granted extended approval for dupilumab as the first biological agent for treatment of insufficiently controlled severe CRSwNP. The Federal Joint Committee (GBA) evaluates the benefits of reimbursable drugs with new active ingredients. This includes assessment of the additional benefit and its therapeutic relevance.METHODS:
A meta-analysis was performed using individual patient data based on two phase III studies. Both studies examined the safety and efficacy of dupilumab as an add-on therapy to INCS for treatment of CRSwNP in adults inadequately controlled with systemic corticosteroids and/or surgery compared to INCS alone.RESULTS:
Based on the present data, the GBA decided that there is an indication of a considerable additional benefit of dupilumab compared to mometasone furoate.CONCLUSION:
For patients with severe CRSwNP inadequately controlled with INCS and systemic corticosteroids and/or surgery, there is an indication of a considerable additional benefit for the administration of dupilumab as an add-on therapy to INCS compared to mometasone furoate alone.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Rinitis
/
Pólipos Nasales
Tipo de estudio:
Diagnostic_studies
/
Systematic_reviews
Límite:
Adult
/
Humans
Idioma:
De
Revista:
HNO
Año:
2021
Tipo del documento:
Article