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Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality.
Schunk, Stefan J; Kleber, Marcus E; März, Winfried; Pang, Shichao; Zewinger, Stephen; Triem, Sarah; Ege, Philipp; Reichert, Matthias C; Krawczyk, Marcin; Weber, Susanne N; Jaumann, Isabella; Schmit, David; Sarakpi, Tamim; Wagenpfeil, Stefan; Kramann, Rafael; Boerwinkle, Eric; Ballantyne, Christie M; Grove, Megan L; Tragante, Vinicius; Pilbrow, Anna P; Richards, A Mark; Cameron, Vicky A; Doughty, Robert N; Dubé, Marie-Pierre; Tardif, Jean-Claude; Feroz-Zada, Yassamin; Sun, Maxine; Liu, Chang; Ko, Yi-An; Quyyumi, Arshed A; Hartiala, Jaana A; Tang, W H Wilson; Hazen, Stanley L; Allayee, Hooman; McDonough, Caitrin W; Gong, Yan; Cooper-DeHoff, Rhonda M; Johnson, Julie A; Scholz, Markus; Teren, Andrej; Burkhardt, Ralph; Martinsson, Andreas; Smith, J Gustav; Wallentin, Lars; James, Stefan K; Eriksson, Niclas; White, Harvey; Held, Claes; Waterworth, Dawn; Trompet, Stella.
Afiliación
  • Schunk SJ; Department of Internal Medicine IV, Nephrology and Hypertension, Saarland University Hospital, Kirrberger Strasse, Building 41, 66424 Homburg/Saar, Germany.
  • Kleber ME; Vth Department of Medicine, University Heidelberg, Mannheim Medical Faculty, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
  • März W; SYNLAB MVZ Humangenetik Mannheim, Harrlachweg 1, 68163 Mannheim, Germany.
  • Pang S; Vth Department of Medicine, University Heidelberg, Mannheim Medical Faculty, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
  • Zewinger S; Clinical Institute of Medical and Laboratory Diagnostics, Medical University Graz, Auenbruggerpl. 2, 8036 Graz, Austria.
  • Triem S; Synlab Academy, Synlab Holding GmbH, Harrlachweg 1, 68163 Mannheim, Germany.
  • Ege P; Kardiologie, Deutsches Herzzentrum München, Technische Universität München, Lazarettstraße 36, 80636 Munich, Germany.
  • Reichert MC; Department of Internal Medicine IV, Nephrology and Hypertension, Saarland University Hospital, Kirrberger Strasse, Building 41, 66424 Homburg/Saar, Germany.
  • Krawczyk M; Department of Internal Medicine IV, Nephrology and Hypertension, Saarland University Hospital, Kirrberger Strasse, Building 41, 66424 Homburg/Saar, Germany.
  • Weber SN; Department of Internal Medicine IV, Nephrology and Hypertension, Saarland University Hospital, Kirrberger Strasse, Building 41, 66424 Homburg/Saar, Germany.
  • Jaumann I; Department of Medicine II, Saarland University Medical Center, Kirrberger Straße, 66424 Homburg, Germany.
  • Schmit D; Department of Medicine II, Saarland University Medical Center, Kirrberger Straße, 66424 Homburg, Germany.
  • Sarakpi T; Laboratory of Metabolic Liver Diseases, Centre for Preclinical Research, Department of General, Transplant and Liver Surgery, Medical University of Warsaw, ul. Banacha 1B, CePT, 02-097 Warsaw, Poland.
  • Wagenpfeil S; Department of Medicine II, Saarland University Medical Center, Kirrberger Straße, 66424 Homburg, Germany.
  • Kramann R; Department of Internal Medicine IV, Nephrology and Hypertension, Saarland University Hospital, Kirrberger Strasse, Building 41, 66424 Homburg/Saar, Germany.
  • Boerwinkle E; Department of Internal Medicine IV, Nephrology and Hypertension, Saarland University Hospital, Kirrberger Strasse, Building 41, 66424 Homburg/Saar, Germany.
  • Ballantyne CM; Department of Internal Medicine IV, Nephrology and Hypertension, Saarland University Hospital, Kirrberger Strasse, Building 41, 66424 Homburg/Saar, Germany.
  • Grove ML; Institute of Medical Biometry, Epidemiology & Medical Informatics, Saarland University Campus Homburg/Saar, Kirrberger Straße, 66424 Homburg/Saar, Germany.
  • Tragante V; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Pauwelsstrasse 30 52074 Aachen, Germany.
  • Pilbrow AP; Institute of Experimental Medicine and Systems Biology, RWTH, Pauwelsstraße 30, 52074 Aachen, Germany.
  • Richards AM; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, 1200 Pressler Street, Houston, TX 77030, USA.
  • Cameron VA; Human Genome Sequencing Center, Baylor College of Medicine, BCM226, Houston, TX 77030, USA.
  • Doughty RN; Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
  • Dubé MP; Center of Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, 6565 Fannin St, Houston, TX 77030, USA.
  • Tardif JC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, 1200 Pressler Street, Houston, TX 77030, USA.
  • Feroz-Zada Y; Department of Cardiology, Heart and Lungs Division, UMC Utrecht, Heidelberglaan 100 3584 CX Utrecht, Netherlands.
  • Sun M; The Christchurch Heart Institute, University of Otago Christchurch, 2 Riccarton Avenue, Christchurch Central City, Christchurch 8011, New Zealand.
  • Liu C; The Christchurch Heart Institute, University of Otago Christchurch, 2 Riccarton Avenue, Christchurch Central City, Christchurch 8011, New Zealand.
  • Ko YA; The Christchurch Heart Institute, University of Otago Christchurch, 2 Riccarton Avenue, Christchurch Central City, Christchurch 8011, New Zealand.
  • Quyyumi AA; Heart Health Research Group, University of Auckland, Level 2 / 22-30 Park Ave, Grafton, Auckland, New Zealand.
  • Hartiala JA; Montreal Heart Institute, 5000 Rue Bélanger, Montreal QC H1T 1C8, Canada.
  • Tang WHW; Faculty of Medicine, Université der Montréal, Pavillon Roger-Gaudry, 2900 Edouard Montpetit Blvd, Montreal, Quebec H3T 1J4, Canada.
  • Hazen SL; Montreal Heart Institute, 5000 Rue Bélanger, Montreal QC H1T 1C8, Canada.
  • Allayee H; Faculty of Medicine, Université der Montréal, Pavillon Roger-Gaudry, 2900 Edouard Montpetit Blvd, Montreal, Quebec H3T 1J4, Canada.
  • McDonough CW; Montreal Heart Institute, 5000 Rue Bélanger, Montreal QC H1T 1C8, Canada.
  • Gong Y; Faculty of Medicine, Université der Montréal, Pavillon Roger-Gaudry, 2900 Edouard Montpetit Blvd, Montreal, Quebec H3T 1J4, Canada.
  • Cooper-DeHoff RM; Emory Clinical Cardiovascular Research Institute, Division of Cardiology, Emory University School of Medicine, 1462 Clifton Road NE, Atlanta, GA 30322, USA.
  • Johnson JA; Department of Biostatistics and Bioinformatics, Rollins School of Public Healthy, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA.
  • Scholz M; Emory Clinical Cardiovascular Research Institute, Division of Cardiology, Emory University School of Medicine, 1462 Clifton Road NE, Atlanta, GA 30322, USA.
  • Teren A; Department of Preventive Medicine, University of Southern California, Keck School of Medicine, 2001 N. Soto St. Los Angeles, CA 90033, USA.
  • Burkhardt R; Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA.
  • Martinsson A; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, NB 21, Cleveland, OH 44195, USA.
  • Smith JG; Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA.
  • Wallentin L; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, NB 21, Cleveland, OH 44195, USA.
  • James SK; Department of Preventive Medicine, University of Southern California, Keck School of Medicine, 2001 N. Soto St. Los Angeles, CA 90033, USA.
  • Eriksson N; Department of Pharmacotherapy and Translational Research, University of Florida, College of Pharmacy, 1225 Center Drive, HPNP Building, Gainesville, FL 32610-0486, USA.
  • White H; Department of Pharmacotherapy and Translational Research, University of Florida, College of Pharmacy, 1225 Center Drive, HPNP Building, Gainesville, FL 32610-0486, USA.
  • Held C; Department of Pharmacotherapy and Translational Research, University of Florida, College of Pharmacy, 1225 Center Drive, HPNP Building, Gainesville, FL 32610-0486, USA.
  • Waterworth D; Division of Cardiovascular Medicine, Department of Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610, USA.
  • Trompet S; Department of Pharmacotherapy and Translational Research, University of Florida, College of Pharmacy, 1225 Center Drive, HPNP Building, Gainesville, FL 32610-0486, USA.
Eur Heart J ; 42(18): 1742-1756, 2021 05 07.
Article en En | MEDLINE | ID: mdl-33748830
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Inflamasomas / Proteína con Dominio Pirina 3 de la Familia NLR / Inflamación Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Eur Heart J Año: 2021 Tipo del documento: Article País de afiliación: Alemania
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Inflamasomas / Proteína con Dominio Pirina 3 de la Familia NLR / Inflamación Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Eur Heart J Año: 2021 Tipo del documento: Article País de afiliación: Alemania