Intravenous administration of mesenchymal stem cells reduces Tau phosphorylation and inflammation in the 3xTg-AD mouse model of Alzheimer's disease.

Neves, Amanda Ferreira; Camargo, Christian; Premer, Courtney; Hare, Joshua M; Baumel, Bernard S; Pinto, Milena

Neves, Amanda Ferreira; Camargo, Christian; Premer, Courtney; Hare, Joshua M; Baumel, Bernard S; Pinto, Milena.

Afiliación

Neves AF; University of Miami Miller School of Medicine, Department of Neurology, 1420 NW 9th Avenue, Miami, FL 33136, United States of America. Electronic address: afn25@med.miami.edu.
Camargo C; University of Miami Miller School of Medicine, Department of Neurology, 1150 Northwest 14th Street, Miami, FL 33136, United States of America. Electronic address: ccamargo@med.miami.edu.
Premer C; Interdisciplinary Stem Cell Institute, Biomedical Research Building, 1501 NW 10th Avenue, Suite 909, Miami, FL 33136, United States of America. Electronic address: cpremer@med.miami.edu.
Hare JM; Interdisciplinary Stem Cell Institute, Biomedical Research Building, 1501 NW 10th Avenue, Suite 909, Miami, FL 33136, United States of America. Electronic address: jhare@med.miami.edu.
Baumel BS; University of Miami Miller School of Medicine, Department of Neurology, 1150 Northwest 14th Street, Miami, FL 33136, United States of America. Electronic address: b.baumel@med.miami.edu.
Pinto M; University of Miami Miller School of Medicine, Department of Neurology, 1420 NW 9th Avenue, Miami, FL 33136, United States of America. Electronic address: mpinto@med.miami.edu.

Exp Neurol ; 341: 113706, 2021 07.

Article en En | MEDLINE | ID: mdl-33757765

Asunto(s)

Enfermedad de Alzheimer/metabolismo; Enfermedad de Alzheimer/terapia; Trasplante de Células Madre Mesenquimatosas/métodos; Proteínas tau/antagonistas & inhibidores; Proteínas tau/metabolismo; Administración Intravenosa; Enfermedad de Alzheimer/genética; Péptidos beta-Amiloides/antagonistas & inhibidores; Péptidos beta-Amiloides/genética; Péptidos beta-Amiloides/metabolismo; Animales; Femenino; Hipocampo/metabolismo; Inflamación/genética; Inflamación/metabolismo; Inflamación/terapia; Células Madre Mesenquimatosas; Ratones; Ratones de la Cepa 129; Ratones Transgénicos; Fragmentos de Péptidos/antagonistas & inhibidores; Fragmentos de Péptidos/genética; Fragmentos de Péptidos/metabolismo; Fosforilación/fisiología; Proteínas tau/genética

Palabras clave

3xTg-AD mice; Alzheimer's disease; Amyloid-ß; Mesenchymal stem cells; Neuroinflammation; Tau phosphorylation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas tau / Trasplante de Células Madre Mesenquimatosas / Enfermedad de Alzheimer Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Exp Neurol Año: 2021 Tipo del documento: Article

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