The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization.
NPJ Vaccines
; 6(1): 44, 2021 Mar 25.
Article
en En
| MEDLINE
| ID: mdl-33767200
ABSTRACT
Initial COVID-19 vaccine candidates were based on the original sequence of SARS-CoV-2. However, the virus has since accumulated mutations, among which the spike D614G is dominant in circulating virus, raising questions about potential virus escape from vaccine-elicited immunity. Here, we report that the D614G mutation modestly reduced (1.7-2.4-fold) SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
NPJ Vaccines
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos