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Francisella tularensis human infections in a village of northwest Iran.
Esmaeili, Saber; Rohani, Mahdi; Ghasemi, Ahmad; Gouya, Mohammad Mehdi; Khayatzadeh, Simin; Mahmoudi, Ahmad; Ahangari Cohan, Hossein; Johansson, Anders; Maurin, Max; Mostafavi, Ehsan.
Afiliación
  • Esmaeili S; National Reference laboratory for Plague, Tularemia and Q fever, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran.
  • Rohani M; Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Tehran, Iran.
  • Ghasemi A; National Reference laboratory for Plague, Tularemia and Q fever, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran.
  • Gouya MM; Department of Microbiology, Pasteur Institute of Iran, Tehran, Iran.
  • Khayatzadeh S; National Reference laboratory for Plague, Tularemia and Q fever, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran.
  • Mahmoudi A; Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Tehran, Iran.
  • Ahangari Cohan H; Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
  • Johansson A; Center for Communicable Disease Control, Ministry of Health and Medical Education, Tehran, Iran.
  • Maurin M; Department of Communicable Disease Control, Deputy of Health, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Mostafavi E; Department of Biology, Faculty of Science, Urmia University, Urmia, Iran.
BMC Infect Dis ; 21(1): 310, 2021 Mar 31.
Article en En | MEDLINE | ID: mdl-33789598
ABSTRACT

BACKGROUND:

Recent seroepidemiological studies have suggested that tularemia could be an endemic bacterial zoonosis in Iran.

METHODS:

From January 2016 to June 2018, disease cases characterized by fever, cervical lymphadenopathy and ocular involvement were reported in Youzband Village of Kaleybar County, in the East Azerbaijan Province, northwestern Iran. Diagnostic tests included Francisella tularensis serology (including tube agglutination test and ELISA), PCR, and culture.

RESULTS:

Among 11 examined case-patients, the tularemia tube agglutination test was positive in ten and borderline in one. PCR detected the F. tularensis ISFtu2 elements and fopA gene in one rodent and a spring water sample from the same geographic area.

CONCLUSIONS:

Based on the clinical manifestations of the disease suggesting an oropharyngeal form of tularemia, serology results in case patients, and F. tularensis detection in the local fauna and aquatic environment, the water supply of the village was the likely source of the tularemia outbreak. Intervention such as dredging and chlorination of the main water storage tank of the village and training of villagers and health care workers in preventive measures and treatment of the illness helped control the infection.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tularemia / Francisella tularensis Límite: Adolescent / Adult / Aged / Animals / Child / Child, preschool / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: BMC Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2021 Tipo del documento: Article País de afiliación: Irán

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tularemia / Francisella tularensis Límite: Adolescent / Adult / Aged / Animals / Child / Child, preschool / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: BMC Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2021 Tipo del documento: Article País de afiliación: Irán