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CRISPR/Cas9 generated knockout mice lacking phenylalanine hydroxylase protein as a novel preclinical model for human phenylketonuria.
Singh, Kuldeep; Cornell, Cathleen S; Jackson, Robert; Kabiri, Mostafa; Phipps, Michael; Desai, Mitul; Fogle, Robert; Ying, Xiaoyou; Anarat-Cappillino, Gulbenk; Geller, Sarah; Johnson, Jennifer; Roberts, Errin; Malley, Katie; Devlin, Tim; DeRiso, Matthew; Berthelette, Patricia; Zhang, Yao V; Ryan, Susan; Rao, Srinivas; Thurberg, Beth L; Bangari, Dinesh S; Kyostio-Moore, Sirkka.
Afiliación
  • Singh K; Global Discovery Pathology, Translational In-Vivo Models Research Platform, Sanofi, 5 The Mountain Road, Framingham, MA, 01701, USA.
  • Cornell CS; WuXi AppTec Inc., 8th Floor, 55 Cambridge Parkway, Cambridge, MA, 02142, USA.
  • Jackson R; Genomic Medicine Unit, Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA.
  • Kabiri M; Genomic Medicine Unit, Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA.
  • Phipps M; Transgenic Model and Technology, Translational In-Vivo Research Platform, Industrie Park Hoechst, Sanofi, Frankfurt, Germany.
  • Desai M; Transgenic Model and Technology, Translational In-Vivo Models Research Platform, Sanofi, 5 The Mountain Road, Framingham, MA, 01701, USA.
  • Fogle R; Global Bioimaging, Translational In-Vivo Models Research Platform, Sanofi, Framingham, MA, 01701, USA.
  • Ying X; Global Bioimaging, Translational In-Vivo Models Research Platform, Sanofi, Framingham, MA, 01701, USA.
  • Anarat-Cappillino G; Global Bioimaging, Translational In-Vivo Models Research Platform, Sanofi, Framingham, MA, 01701, USA.
  • Geller S; Pre-Development Sciences NA, Analytical R&D, Sanofi, Framingham, MA, 01701, USA.
  • Johnson J; Pre-Development Sciences NA, Analytical R&D, Sanofi, Framingham, MA, 01701, USA.
  • Roberts E; Global Discovery Pathology, Translational In-Vivo Models Research Platform, Sanofi, 5 The Mountain Road, Framingham, MA, 01701, USA.
  • Malley K; Global Discovery Pathology, Translational In-Vivo Models Research Platform, Sanofi, 5 The Mountain Road, Framingham, MA, 01701, USA.
  • Devlin T; Global Discovery Pathology, Translational In-Vivo Models Research Platform, Sanofi, 5 The Mountain Road, Framingham, MA, 01701, USA.
  • DeRiso M; Transgenic Model and Technology, Translational In-Vivo Models Research Platform, Sanofi, 5 The Mountain Road, Framingham, MA, 01701, USA.
  • Berthelette P; Transgenic Model and Technology, Translational In-Vivo Models Research Platform, Sanofi, 5 The Mountain Road, Framingham, MA, 01701, USA.
  • Zhang YV; Genomic Medicine Unit, Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA.
  • Ryan S; Genomic Medicine Unit, Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA.
  • Rao S; Global Discovery Pathology, Translational In-Vivo Models Research Platform, Sanofi, 5 The Mountain Road, Framingham, MA, 01701, USA.
  • Thurberg BL; Translational In-Vivo Models Research Platform, Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA.
  • Bangari DS; Global Discovery Pathology, Translational In-Vivo Models Research Platform, Sanofi, 5 The Mountain Road, Framingham, MA, 01701, USA.
  • Kyostio-Moore S; Global Discovery Pathology, Translational In-Vivo Models Research Platform, Sanofi, 5 The Mountain Road, Framingham, MA, 01701, USA. dinesh.bangari@sanofi.com.
Sci Rep ; 11(1): 7254, 2021 03 31.
Article en En | MEDLINE | ID: mdl-33790381
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fenilalanina Hidroxilasa / Fenilcetonurias / Modelos Animales de Enfermedad / Técnicas de Inactivación de Genes / Sistemas CRISPR-Cas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fenilalanina Hidroxilasa / Fenilcetonurias / Modelos Animales de Enfermedad / Técnicas de Inactivación de Genes / Sistemas CRISPR-Cas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos