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Cognitive Impairment After Resolution of Hepatic Encephalopathy: A Systematic Review and Meta-Analysis.
López-Franco, Óscar; Morin, Jean-Pascal; Cortés-Sol, Albertina; Molina-Jiménez, Tania; Del Moral, Diana I; Flores-Muñoz, Mónica; Roldán-Roldán, Gabriel; Juárez-Portilla, Claudia; Zepeda, Rossana C.
Afiliación
  • López-Franco Ó; Laboratorio de Medicina Traslacional, Instituto de Ciencias de la Salud, Universidad Veracruzana, Xalapa, Mexico.
  • Morin JP; Laboratorio de Neurobiología de la Conducta, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de Mexico, Ciudad de Mexico, Mexico.
  • Cortés-Sol A; Facultad de Biología-Xalapa, Universidad Veracruzana, Xalapa, Mexico.
  • Molina-Jiménez T; Instituto Interdisciplinario de Investigaciones de la Universidad de Xalapa, Xalapa, Mexico.
  • Del Moral DI; Programa de Doctorado en Ciencias Biomédicas, Universidad Veracruzana, Xalapa, Mexico.
  • Flores-Muñoz M; Laboratorio de Medicina Traslacional, Instituto de Ciencias de la Salud, Universidad Veracruzana, Xalapa, Mexico.
  • Roldán-Roldán G; Laboratorio de Neurobiología de la Conducta, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de Mexico, Ciudad de Mexico, Mexico.
  • Juárez-Portilla C; Laboratorio de Biomedicina Integral y Salud, Centro de Investigaciones Biomédicas, Universidad Veracruzana, Xalapa, Mexico.
  • Zepeda RC; Laboratorio de Biomedicina Integral y Salud, Centro de Investigaciones Biomédicas, Universidad Veracruzana, Xalapa, Mexico.
Front Neurosci ; 15: 579263, 2021.
Article en En | MEDLINE | ID: mdl-33790729
Hepatic encephalopathy (HE) is one of the most disabling metabolic diseases. It consists of a complication of liver disease through the action of neurotoxins, such as excessive production of ammonia from liver, resulting in impaired brain function. Its prevalence and incidence are not well known, although it has been established that up to 40% of cirrhotic patients may develop HE. Patients with HE episodes display a wide range of neurological disturbances, from subclinical alterations to coma. Recent evidence suggests that the resolution of hepatic encephalopathy does not fully restore cognitive functioning in cirrhotic patients. Therefore, the aim of this review was to evaluate the evidence supporting the presence of lingering cognitive deficits in patients with a history of HE compared to patients without HE history and how liver transplant affects such outcome in these patients. We performed two distinct meta-analysis of continuous outcomes. In both cases the results were pooled using random-effects models. Our results indicate that cirrhotic patients with a history of HE show clear cognitive deficits compared control cirrhotic patients (Std. Mean Difference (in SDs) = -0.72 [CI 95%: -0.94, -0.50]) and that these differences are not fully restored after liver transplant (Std. Mean Difference (in SDs) = -0.72 [CI 95%: -0.94, -0.50]).
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: Front Neurosci Año: 2021 Tipo del documento: Article País de afiliación: México

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: Front Neurosci Año: 2021 Tipo del documento: Article País de afiliación: México