Birth characteristics and risk of febrile seizures.
Acta Neurol Scand
; 144(1): 51-57, 2021 Jul.
Article
en En
| MEDLINE
| ID: mdl-33822360
ABSTRACT
OBJECTIVE:
Febrile seizure is a common childhood disorder that affects 2-5% of all children, and is associated with later development of epilepsy and psychiatric disorders. This study determines how the incidence of febrile seizures correlates with birth characteristics, age, sex and brain development.METHODS:
This is a cohort study of all children born Denmark between 1977 and 2011 who were alive at 3 months of age (N = 2,103,232). The Danish National Patient Register was used to identify children with febrile seizures up to 5 years of age. Follow-up ended on 31 December 2016 when all cohort members had potentially reached 5 years of age.RESULTS:
In total, 75,593 (3.59%, 95% CI 3.57-3.62%) were diagnosed with febrile seizures. Incidence peaked at 16.7 months of age (median 16.7 months, interquartile range 12.5-24.0). The 5-year cumulative incidence of febrile seizures increased with decreasing birth weight (<1500 g; 5.42% (95% CI 4.98-5.88% vs. 3,000-4,000 g; 3.53% (95% CI 3.50-3.56%)) and with decreasing gestational age at birth (31-32 weeks; 5.90% (95% CI 5.40-6.44%) vs. 39-40 weeks; 3.56% (95% CI 3.53-3.60)). Lower gestational age at birth was associated with higher age at onset of a first febrile seizure; an association that essentially disappeared when correcting for age from conception.CONCLUSIONS:
The risk of febrile seizures increased with decreasing birth weight and gestational age at birth. The association between low gestational age at birth and age at first febrile seizure suggests that onset of febrile seizures is associated with the stage of brain development.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Peso al Nacer
/
Desarrollo Infantil
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Edad Gestacional
/
Convulsiones Febriles
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Límite:
Child, preschool
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Humans
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Infant
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Male
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Newborn
País/Región como asunto:
Europa
Idioma:
En
Revista:
Acta Neurol Scand
Año:
2021
Tipo del documento:
Article
País de afiliación:
Dinamarca