Neuronal Differentiation 1 gene Ala45Thr polymorphism and type 2 diabetes mellitus: A meta-analysis of 7,940 subjects.
Nutr Metab Cardiovasc Dis
; 31(6): 1809-1821, 2021 06 07.
Article
en En
| MEDLINE
| ID: mdl-33893004
ABSTRACT
BACKGROUND AND AIMS:
Previous studies have shown that there was a possible relationship between human Neuronal Differentiation 1 (NEUROD1) gene Ala45Thr polymorphism and type 2 diabetes mellitus (T2DM) susceptibility. Nevertheless, no public opinion has been formed because of the conflicting results in the past studies. In order to illuminate the potential association of human NEUROD1 gene Ala45Thr polymorphism and T2DM, the present meta-analysis was conducted. METHODS ANDRESULTS:
In the current meta-analysis, 7940 subjects from 14 individual studies were included. The fixed or random effects models were used to evaluate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). The current meta-analysis found a significant association between NEUROD1 gene Ala45Thr polymorphism and T2DM under allelic (OR 1.21, 95% CI 1.04-1.41, P = 0.01), dominant (OR 0.819, 95% CI 0.734-0.913, P = 3.31 × 10-4), heterozygous (OR1.199, 95% CI 1.068-1.346, P = 0.002), and additive (OR 1.33, 95% CI 1.09-1.62, P = 0.004) genetic models.CONCLUSIONS:
NEUROD1 gene Ala45Thr polymorphism was significantly related to T2DM, especially in the Asian population. More particularly, the Thr45 allele carriers of the NEUROD1 gene may be more susceptible to T2DM.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
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Diabetes Mellitus Tipo 2
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Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Nutr Metab Cardiovasc Dis
Asunto de la revista:
ANGIOLOGIA
/
CARDIOLOGIA
/
CIENCIAS DA NUTRICAO
/
METABOLISMO
Año:
2021
Tipo del documento:
Article