Neuronal Differentiation 1 gene Ala45Thr polymorphism and type 2 diabetes mellitus: A meta-analysis of 7,940 subjects.

ABSTRACT

BACKGROUND AND AIMS: Previous studies have shown that there was a possible relationship between human Neuronal Differentiation 1 (NEUROD1) gene Ala45Thr polymorphism and type 2 diabetes mellitus (T2DM) susceptibility. Nevertheless, no public opinion has been formed because of the conflicting results in the past studies. In order to illuminate the potential association of human NEUROD1 gene Ala45Thr polymorphism and T2DM, the present meta-analysis was conducted. METHODS AND RESULTS: In the current meta-analysis, 7940 subjects from 14 individual studies were included. The fixed or random effects models were used to evaluate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). The current meta-analysis found a significant association between NEUROD1 gene Ala45Thr polymorphism and T2DM under allelic (OR 1.21, 95% CI 1.04-1.41, P = 0.01), dominant (OR 0.819, 95% CI 0.734-0.913, P = 3.31 × 10-4), heterozygous (OR1.199, 95% CI 1.068-1.346, P = 0.002), and additive (OR 1.33, 95% CI 1.09-1.62, P = 0.004) genetic models. CONCLUSIONS: NEUROD1 gene Ala45Thr polymorphism was significantly related to T2DM, especially in the Asian population. More particularly, the Thr45 allele carriers of the NEUROD1 gene may be more susceptible to T2DM.