New triterpenoid saponins from the leaves of Ilex chinensis and their hepatoprotective activity.
Chin J Nat Med
; 19(5): 376-384, 2021 May.
Article
en En
| MEDLINE
| ID: mdl-33941342
ABSTRACT
Seven new triterpenoid saponins, including five ursane-type saponins, ilexchinenosides R-V (1-5), and two oleanane-type saponins, ilexchinenosides W-X (6-7), with four known triterpenoid saponins (8-11) were isolated from the leaves of Ilex chinensis. Their structures were elucidated by comprehensive spectroscopic 1D and 2D NMR and HR-ESI-MS data. Their sugar moieties were determined by HPLC analysis compared with standards after hydrolysis and derivatization. Compounds 1, 2, 4, 9 and 10 exhibited potential hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell injury in vitro.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Saponinas
/
Triterpenos
/
Sustancias Protectoras
/
Ilex
Límite:
Humans
Idioma:
En
Revista:
Chin J Nat Med
Año:
2021
Tipo del documento:
Article
País de afiliación:
China