Interrupted aza-Wittig reactions using iminophosphoranes to synthesize <sup>11</sup>C-carbonyls.

Ismailani, Uzair S; Munch, Maxime; Mair, Braeden A; Rotstein, Benjamin H

Interrupted aza-Wittig reactions using iminophosphoranes to synthesize ¹¹C-carbonyls.

Ismailani, Uzair S; Munch, Maxime; Mair, Braeden A; Rotstein, Benjamin H.

Afiliación

Ismailani US; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Canada. benjamin.rotstein@uottawa.ca and University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, Canada.
Munch M; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Canada. benjamin.rotstein@uottawa.ca and University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, Canada.
Mair BA; University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, Canada and Department of Chemistry and Biomolecular Sciences, University of Ottawa, Canada.
Rotstein BH; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Canada. benjamin.rotstein@uottawa.ca and University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, Canada and Department of Chemistry and Biomolecular Sciences, University of Ottawa, Canada.

Chem Commun (Camb) ; 57(43): 5266-5269, 2021 May 27.

Article en En | MEDLINE | ID: mdl-33942043

ABSTRACT

ABSTRACT

A direct CO2-fixation methodology couples structurally diverse iminophosphoranes with various nucleophiles to synthesize ureas, carbamates, thiocarbamates, and amides, and is amenable for 11C radiolabeling. This methodology is practical, as demonstrated by the synthesis of >35 products and isolation of the molecular imaging radiopharmaceuticals [11C]URB694 and [11C]glibenclamide.

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Canadá

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