Inhibitors of Protein Glycosylation Are Active against the Coronavirus Severe Acute Respiratory Syndrome Coronavirus SARS-CoV-2.

Rajasekharan, Sreejith; Milan Bonotto, Rafaela; Nascimento Alves, Lais; Kazungu, Yvette; Poggianella, Monica; Martinez-Orellana, Pamela; Skoko, Natasa; Polez, Sulena; Marcello, Alessandro

Rajasekharan, Sreejith; Milan Bonotto, Rafaela; Nascimento Alves, Lais; Kazungu, Yvette; Poggianella, Monica; Martinez-Orellana, Pamela; Skoko, Natasa; Polez, Sulena; Marcello, Alessandro.

Afiliación

Rajasekharan S; Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB) Padriciano, 99-34149 Trieste, Italy.
Milan Bonotto R; Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB) Padriciano, 99-34149 Trieste, Italy.
Nascimento Alves L; Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB) Padriciano, 99-34149 Trieste, Italy.
Kazungu Y; Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB) Padriciano, 99-34149 Trieste, Italy.
Poggianella M; Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB) Padriciano, 99-34149 Trieste, Italy.
Martinez-Orellana P; Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB) Padriciano, 99-34149 Trieste, Italy.
Skoko N; Biotechnology Development, International Centre for Genetic Engineering and Biotechnology (ICGEB) Padriciano, 99-34149 Trieste, Italy.
Polez S; Biotechnology Development, International Centre for Genetic Engineering and Biotechnology (ICGEB) Padriciano, 99-34149 Trieste, Italy.
Marcello A; Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB) Padriciano, 99-34149 Trieste, Italy.

Viruses ; 13(5)2021 04 30.

Article en En | MEDLINE | ID: mdl-33946304

Asunto(s)

1-Desoxinojirimicina/análogos & derivados; Antivirales/farmacología; Reposicionamiento de Medicamentos; Inhibidores de Glicósido Hidrolasas/farmacología; Indolizinas/farmacología; SARS-CoV-2/efectos de los fármacos; 1-Desoxinojirimicina/farmacología; Células A549; Animales; Chlorocebus aethiops; Glicosilación/efectos de los fármacos; Células HEK293; Humanos; Glicoproteína de la Espiga del Coronavirus/metabolismo; Células Vero; Liberación del Virus/efectos de los fármacos; Tratamiento Farmacológico de COVID-19

Palabras clave

COVID-19; Celgosivir; Miglustat; SARS-CoV-2; antiviral; coronavirus; inhibitor; spike

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antivirales / 1-Desoxinojirimicina / Reposicionamiento de Medicamentos / Inhibidores de Glicósido Hidrolasas / SARS-CoV-2 / Indolizinas Límite: Animals / Humans Idioma: En Revista: Viruses Año: 2021 Tipo del documento: Article País de afiliación: Italia

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