(±)-Gancochlearols J - N, renoprotective meroterpenoids from Ganoderma cochlear.
Bioorg Chem
; 112: 104950, 2021 07.
Article
en En
| MEDLINE
| ID: mdl-33962091
ABSTRACT
Five pairs of meroterpenoid enantiomers, (±)-gancochlearols J - N (1-5), were isolated from the fruiting bodies of Ganoderma cochlear. Their structures were elucidated on the basis of 1D and 2D NMR and HRESIMS data. The absolute configurations of gancochlearols J - M (1-4) were assigned by electronic circular dichroism (ECD) calculations. Biological evaluation showed that (-)-1 and (-)-2 could inhibit renal fibrosis in TGF-ß1-induced rat kidney proximal tubular cells (NRK-52e).
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Terpenos
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Fibrosis
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Ganoderma
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Cuerpos Fructíferos de los Hongos
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Factor de Crecimiento Transformador beta1
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Túbulos Renales Proximales
Límite:
Animals
Idioma:
En
Revista:
Bioorg Chem
Año:
2021
Tipo del documento:
Article