Your browser doesn't support javascript.
loading
(±)-Gancochlearols J - N, renoprotective meroterpenoids from Ganoderma cochlear.
Meng, Xiao-Hui; Qin, Fu-Ying; Jiang, Xiao-Ting; Li, Yu; Cheng, Yong-Xian.
Afiliación
  • Meng XH; School of Medicine, Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, People's Republic of China; School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, People's Republic of China.
  • Qin FY; School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, People's Republic of China.
  • Jiang XT; School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, People's Republic of China.
  • Li Y; School of Medicine, Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, People's Republic of China. Electronic address: liyu@njucm.edu.cn.
  • Cheng YX; School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, People's Republic of China; Guangdong Key Laboratory for Functional Substances in Medicinal Edible Resources and Healthcare Products, School of Life Sciences and Food Engineering, Hanshan Normal University
Bioorg Chem ; 112: 104950, 2021 07.
Article en En | MEDLINE | ID: mdl-33962091
ABSTRACT
Five pairs of meroterpenoid enantiomers, (±)-gancochlearols J - N (1-5), were isolated from the fruiting bodies of Ganoderma cochlear. Their structures were elucidated on the basis of 1D and 2D NMR and HRESIMS data. The absolute configurations of gancochlearols J - M (1-4) were assigned by electronic circular dichroism (ECD) calculations. Biological evaluation showed that (-)-1 and (-)-2 could inhibit renal fibrosis in TGF-ß1-induced rat kidney proximal tubular cells (NRK-52e).
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Terpenos / Fibrosis / Ganoderma / Cuerpos Fructíferos de los Hongos / Factor de Crecimiento Transformador beta1 / Túbulos Renales Proximales Límite: Animals Idioma: En Revista: Bioorg Chem Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Terpenos / Fibrosis / Ganoderma / Cuerpos Fructíferos de los Hongos / Factor de Crecimiento Transformador beta1 / Túbulos Renales Proximales Límite: Animals Idioma: En Revista: Bioorg Chem Año: 2021 Tipo del documento: Article