The SHREAD gene therapy platform for paracrine delivery improves tumor localization and intratumoral effects of a clinical antibody.

Smith, Sheena N; Schubert, Rajib; Simic, Branko; Brücher, Dominik; Schmid, Markus; Kirk, Niels; Freitag, Patrick C; Gradinaru, Viviana; Plückthun, Andreas

Smith, Sheena N; Schubert, Rajib; Simic, Branko; Brücher, Dominik; Schmid, Markus; Kirk, Niels; Freitag, Patrick C; Gradinaru, Viviana; Plückthun, Andreas.

Afiliación

Smith SN; Department of Biochemistry, University of Zürich, 8057 Zürich, Switzerland; s.smith@bioc.uzh.ch plueckthun@bioc.uzh.ch.
Schubert R; Department of Biochemistry, University of Zürich, 8057 Zürich, Switzerland.
Simic B; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Brücher D; Department of Biochemistry, University of Zürich, 8057 Zürich, Switzerland.
Schmid M; Department of Biochemistry, University of Zürich, 8057 Zürich, Switzerland.
Kirk N; Department of Biochemistry, University of Zürich, 8057 Zürich, Switzerland.
Freitag PC; Department of Biochemistry, University of Zürich, 8057 Zürich, Switzerland.
Gradinaru V; Department of Biochemistry, University of Zürich, 8057 Zürich, Switzerland.
Plückthun A; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.

Proc Natl Acad Sci U S A ; 118(21)2021 05 25.

Article en En | MEDLINE | ID: mdl-34001602

Asunto(s)

Anticuerpos/farmacología; Sistemas de Liberación de Medicamentos; Terapia Genética; Neoplasias/tratamiento farmacológico; Adenoviridae/genética; Animales; Anticuerpos/genética; Anticuerpos/inmunología; Antígenos de Superficie/genética; Antineoplásicos/farmacología; Vectores Genéticos/genética; Vectores Genéticos/farmacología; Humanos; Imagenología Tridimensional; Ratones; Neoplasias/genética; Neoplasias/inmunología; Neoplasias/patología; Comunicación Paracrina/efectos de los fármacos

Palabras clave

3D reconstruction; PACT tissue clearing; adenovirus; cancer therapy; gene therapy

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Terapia Genética / Sistemas de Liberación de Medicamentos / Anticuerpos / Neoplasias Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article

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