Driving effect of BDNF in the spinal dorsal horn on neuropathic pain.
Neurosci Lett
; 756: 135965, 2021 06 21.
Article
en En
| MEDLINE
| ID: mdl-34022262
ABSTRACT
Neuropathic pain (NP) is caused by direct or indirect damage to the nervous system and is a common symptom of many diseases. The mechanisms underlying the onset and persistence of NP are unclear. Therefore, research concerning these mechanisms has become an important focus in the medical field. Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family of signaling molecules. BDNF is an important regulator of neuronal development, synaptic transmission, and cellular and synaptic plasticity, which are essential for nerve maintenance and repair. However, BDNF is upregulated in the spinal dorsal horn and can promote NP by activating glial cells, reducing inhibitory functions and enhancing excitement after nociceptive stimulation. This review considers the relationship between NP and BDNF signaling in the spinal dorsal horn and discusses potentially related pathological mechanisms.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Transducción de Señal
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Factor Neurotrófico Derivado del Encéfalo
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Células del Asta Posterior
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Asta Dorsal de la Médula Espinal
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Neuralgia
Límite:
Animals
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Humans
Idioma:
En
Revista:
Neurosci Lett
Año:
2021
Tipo del documento:
Article