New bis([1,2,4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers: Design, synthesis, in silico studies, and anticancer evaluation.

Alanazi, Mohammed M; Mahdy, Hazem A; Alsaif, Nawaf A; Obaidullah, Ahmad J; Alkahtani, Hamad M; Al-Mehizia, Abdulrahman A; Alsubaie, Sultan M; Dahab, Mohammed A; Eissa, Ibrahim H

Alanazi, Mohammed M; Mahdy, Hazem A; Alsaif, Nawaf A; Obaidullah, Ahmad J; Alkahtani, Hamad M; Al-Mehizia, Abdulrahman A; Alsubaie, Sultan M; Dahab, Mohammed A; Eissa, Ibrahim H.

Afiliación

Alanazi MM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, Saudi Arabia. Electronic address: mmalanazi@KSU.EDU.SA.
Mahdy HA; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.
Alsaif NA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, Saudi Arabia.
Obaidullah AJ; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, Saudi Arabia.
Alkahtani HM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, Saudi Arabia.
Al-Mehizia AA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, Saudi Arabia.
Alsubaie SM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, Saudi Arabia.
Dahab MA; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: Mmohammeddahab@azhar.edu.eg.
Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: Ibrahimeissa@azhar.edu.eg.

Bioorg Chem ; 112: 104949, 2021 07.

Article en En | MEDLINE | ID: mdl-34023640

Asunto(s)

Antineoplásicos/farmacología; Apoptosis/efectos de los fármacos; Inhibidores de Proteínas Quinasas/farmacología; Quinoxalinas/farmacología; Triazoles/farmacología; Receptor 2 de Factores de Crecimiento Endotelial Vascular/antagonistas & inhibidores; Antineoplásicos/síntesis química; Antineoplásicos/química; Proliferación Celular/efectos de los fármacos; Relación Dosis-Respuesta a Droga; Diseño de Fármacos; Ensayos de Selección de Medicamentos Antitumorales; Células Hep G2; Humanos; Células MCF-7; Simulación del Acoplamiento Molecular; Estructura Molecular; Inhibidores de Proteínas Quinasas/síntesis química; Inhibidores de Proteínas Quinasas/química; Quinoxalinas/síntesis química; Quinoxalinas/química; Relación Estructura-Actividad; Triazoles/síntesis química; Triazoles/química; Receptor 2 de Factores de Crecimiento Endotelial Vascular/metabolismo

Palabras clave

Anti-proliferative; Apoptosis; Bis([1,2,4]triazolo)[4,3-a:3',4'-c]quinoxaline; Docking studies; VEGFR-2 inhibitors

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Quinoxalinas / Triazoles / Apoptosis / Receptor 2 de Factores de Crecimiento Endotelial Vascular / Inhibidores de Proteínas Quinasas / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2021 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google