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Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic.
Jiang, Jinlong; Ding, Fa-Xiang; Zhou, Xiaoyan; Bateman, Thomas J; Dong, Shuzhi; Gu, Xin; Keh deJesus, Reynalda; Pio, Barbara; Tang, Haifeng; Chobanian, Harry R; Levorse, Dorothy; Hu, Mengwei; Thomas-Fowlkes, Brande; Margulis, Michael; Koehler, Martin; Weinglass, Adam; Gibson, Jack; Houle, Kevin; Yudkovitz, Joel; Hampton, Caryn; Pai, Lee-Yuh; Samuel, Koppara; Cutarelli, Timothy; Sullivan, Kathleen; Parmee, Emma R; Davies, Ian; Pasternak, Alexander.
Afiliación
  • Jiang J; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Ding FX; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Zhou X; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Bateman TJ; Pharmacokinetics Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Dong S; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Gu X; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Keh deJesus R; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Pio B; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Tang H; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Chobanian HR; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Levorse D; Discovery and Preclinical Sciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Hu M; Discovery and Preclinical Sciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Thomas-Fowlkes B; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Margulis M; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Koehler M; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Weinglass A; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Gibson J; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Houle K; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Yudkovitz J; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Hampton C; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Pai LY; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Samuel K; Pharmacokinetics Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Cutarelli T; Discovery Process Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Sullivan K; Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Parmee ER; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Davies I; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
  • Pasternak A; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
J Med Chem ; 64(11): 7691-7701, 2021 06 10.
Article en En | MEDLINE | ID: mdl-34038119
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Canales de Potasio de Rectificación Interna / Bloqueadores de los Canales de Potasio / Natriuréticos Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Canales de Potasio de Rectificación Interna / Bloqueadores de los Canales de Potasio / Natriuréticos Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos