Sinularamides A-G, Terpenoid-Derived Spermidine and Spermine Conjugates with Casitas B-Lineage Lymphoma Proto-Oncogene B (Cbl-b) Inhibitory Activities from a Sinularia sp. Soft Coral.
J Nat Prod
; 84(6): 1831-1837, 2021 06 25.
Article
en En
| MEDLINE
| ID: mdl-34038132
ABSTRACT
An extract of a Sinularia sp. soft coral showed inhibitory activity against the E3-ubiquitin ligase casitas B-lineage lymphoma proto-oncogene B (Cbl-b). Subsequent bioassay-guided separation of the extract provided a series of terpenoid-derived spermidine and spermine amides that were named sinularamides A-G (1-7). Compounds 1-7 represent new natural products; however, sinularamide A (1) was previously reported as a synthetic end product. The structures of sinularamides A-G (1-7) were elucidated by analysis of spectroscopic and spectrometric data from NMR, IR, and HRESIMS experiments and by comparison with literature data. All of the isolated compounds showed Cbl-b inhibitory activities with IC50 values that ranged from approximately 6.5 to 33 µM.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Terpenos
/
Espermidina
/
Espermina
/
Antozoos
/
Proteínas Adaptadoras Transductoras de Señales
/
Proteínas Proto-Oncogénicas c-cbl
Límite:
Animals
Idioma:
En
Revista:
J Nat Prod
Año:
2021
Tipo del documento:
Article