The influence of metabolic control on very low density lipoprotein composition in hypertriglyceridemic type II diabetics. A study using heparin-sepharose chromatography.

ABSTRACT

The composition and heparin-binding capacity of very low density lipoproteins (VLDL) from type II diabetics prone to develop secondary hypertriglyceridemia have been examined. Twelve diabetic patients whose triglyceride levels normalized during short-term treatment for hyperglycemia were studied. Normalization of triglyceride values reduced plasma levels of VLDL without modifying its relative lipid composition. There was, however, an increase in its relative apoprotein (apo) content, to which apo B made a greater percentage contribution. The calculated average particle diameter of posttreatment VLDL was reduced. The fraction of VLDL binding to heparin increased after treatment. Binding was strongly correlated to the apo B content and, to a lesser extent, to the apo E content. The data suggest that treatment of hyperglycemia favorably modified VLDL such that they more closely resemble VLDL from normolipidemic subjects, with potentially beneficial physiological consequences.