MiR-18a Aggravates Intracranial Hemorrhage by Regulating RUNX1-Occludin/ZO-1 Axis to Increase BBB Permeability.

Ren, Siying; Wu, Guofeng; Huang, Yuanxin; Wang, Likun; Li, Yinghui; Zhang, Yan

Ren, Siying; Wu, Guofeng; Huang, Yuanxin; Wang, Likun; Li, Yinghui; Zhang, Yan.

Afiliación

Ren S; Guizhou Medical University, Guiyang 550025, China; Department of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.
Wu G; Guizhou Medical University, Guiyang 550025, China; Department of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China. Electronic address: 1993565938@qq.com.
Huang Y; Department of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.
Wang L; Department of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.
Li Y; Guizhou Medical University, Guiyang 550025, China.
Zhang Y; Guizhou Medical University, Guiyang 550025, China; Department of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.

J Stroke Cerebrovasc Dis ; 30(8): 105878, 2021 Aug.

Article en En | MEDLINE | ID: mdl-34077824

Asunto(s)

Barrera Hematoencefálica/metabolismo; Permeabilidad Capilar; Subunidad alfa 2 del Factor de Unión al Sitio Principal/metabolismo; Hemorragias Intracraneales/metabolismo; MicroARNs/metabolismo; Ocludina/metabolismo; Proteína de la Zonula Occludens-1/metabolismo; Animales; Astrocitos/metabolismo; Astrocitos/patología; Barrera Hematoencefálica/patología; Células Cultivadas; Técnicas de Cocultivo; Subunidad alfa 2 del Factor de Unión al Sitio Principal/genética; Modelos Animales de Enfermedad; Impedancia Eléctrica; Células Endoteliales/metabolismo; Células Endoteliales/patología; Hemorragias Intracraneales/genética; Hemorragias Intracraneales/patología; Masculino; MicroARNs/genética; Ocludina/genética; Ratas Sprague-Dawley; Transducción de Señal; Proteína de la Zonula Occludens-1/genética

Palabras clave

BBB permeability; ICH; Tight junction protein; miR-18a, RUNX1

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Permeabilidad Capilar / Barrera Hematoencefálica / Hemorragias Intracraneales / MicroARNs / Subunidad alfa 2 del Factor de Unión al Sitio Principal / Ocludina / Proteína de la Zonula Occludens-1 Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Stroke Cerebrovasc Dis Asunto de la revista: ANGIOLOGIA / CEREBRO Año: 2021 Tipo del documento: Article País de afiliación: China

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