Zika Virus Infection Associated with Autism Spectrum Disorder: A Case Report.
Neuroimmunomodulation
; 28(4): 229-232, 2021.
Article
en En
| MEDLINE
| ID: mdl-34082423
ABSTRACT
INTRODUCTION:
The aim of this case was to investigate the association of the Zika virus infection in utero with the autism spectrum disorder (ASD) as clinical outcome that presented no congenital anomalies.METHODS:
ASD was diagnosed in the second year of life by different child neurologists and confirmed by DSM-5 and ASQ. After that, an extensive clinical, epidemiological, and genetic evaluations were performed, with main known ASD causes ruled out.RESULTS:
An extensive laboratorial search was done, with normal findings. SNP array identified no pathogenic variants. Normal neuroimaging and EEG findings were also obtained. ZIKV (Zika virus) IgG was positive, while IgM was negative. Other congenital infections were negative. The exome sequencing did not reveal any pathogenic variant in genes related to ASD.CONCLUSION:
Accordingly, this report firstly associates ZIKV exposure to ASD.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Complicaciones Infecciosas del Embarazo
/
Trastorno del Espectro Autista
/
Virus Zika
/
Infección por el Virus Zika
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Child
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Neuroimmunomodulation
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
NEUROLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Brasil