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Elevation of HHV-6 viral load mimicking HHV-6 reactivation after second umbilical cord blood transplantation in chromosomally integrated human herpesvirus-6.
Katagiri, Seiichiro; Akahane, Daigo; Inukai, Tatsuya; Otsuki, Shunsuke; Yamada, Arisa; Moriyama, Mitsuru; Yamada, Akiko; Asano, Michiyo; Yoshizawa, Seiichiro; Tanaka, Yuko; Furuya, Nahoko; Fujimoto, Hiroaki; Gotoh, Moritaka; Nakamura, Shigeki; Gotoh, Akihiko.
Afiliación
  • Katagiri S; Department of Hematology, Tokyo Medical University, Tokyo, Japan. Electronic address: katagiri@tokyo-med.ac.jp.
  • Akahane D; Department of Hematology, Tokyo Medical University, Tokyo, Japan.
  • Inukai T; Department of Microbiology, Tokyo Medical University, Tokyo, Japan.
  • Otsuki S; Department of Hematology, Tokyo Medical University, Tokyo, Japan.
  • Yamada A; Department of Hematology, Tokyo Medical University, Tokyo, Japan.
  • Moriyama M; Department of Hematology, Tokyo Medical University, Tokyo, Japan.
  • Yamada A; Department of Hematology, Tokyo Medical University, Tokyo, Japan.
  • Asano M; Department of Hematology, Tokyo Medical University, Tokyo, Japan.
  • Yoshizawa S; Department of Hematology, Tokyo Medical University, Tokyo, Japan.
  • Tanaka Y; Department of Hematology, Tokyo Medical University, Tokyo, Japan.
  • Furuya N; Department of Hematology, Tokyo Medical University, Tokyo, Japan.
  • Fujimoto H; Department of Hematology, Tokyo Medical University, Tokyo, Japan.
  • Gotoh M; Department of Hematology, Tokyo Medical University, Tokyo, Japan.
  • Nakamura S; Department of Microbiology, Tokyo Medical University, Tokyo, Japan.
  • Gotoh A; Department of Hematology, Tokyo Medical University, Tokyo, Japan.
J Infect Chemother ; 27(10): 1517-1519, 2021 Oct.
Article en En | MEDLINE | ID: mdl-34083146
ABSTRACT
Human herpesvirus-6 (HHV-6) reactivation is an important complication in patients receiving umbilical cord blood transplantation (CBT). Chromosomally integrated human herpesvirus-6 (ciHHV-6) is a condition in which the complete HHV-6 genome is integrated into the host germline genome and is transmitted in a Mendelian manner. The influence of ciHHV-6 in recipients or donors in cases of CBT is unknown. We report the first case with ciHHV-6 that received CBT twice for acute lymphoblastic T-cell leukemia. HHV-6 DNA in peripheral blood leukocytes (PBLs) was examined over time through two CBTs. After the first CBT, the HHV-6 viral load was significantly reduced by conversion to PBLs derived from the first donor. During the second CBT, an increase in HHV-6 DNA in PBLs and plasma were observed. However, HHV-6 mRNA was not detected in either the sample before 2nd CBT or at the time of HHV-6 DNA elevation. It is considered that the HHV-6 DNA detected in PBLs and plasma samples might be the HHV-6 genome released due to tissue damage. This case suggests that physicians should be aware of HHV-6 DNA variability during allogeneic hematopoietic stem cell transplantation in ciHHV-6 patients.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Herpesvirus Humano 6 / Trasplante de Células Madre Hematopoyéticas / Infecciones por Roseolovirus / Trasplante de Células Madre de Sangre del Cordón Umbilical Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: J Infect Chemother Asunto de la revista: MICROBIOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Herpesvirus Humano 6 / Trasplante de Células Madre Hematopoyéticas / Infecciones por Roseolovirus / Trasplante de Células Madre de Sangre del Cordón Umbilical Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: J Infect Chemother Asunto de la revista: MICROBIOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2021 Tipo del documento: Article