Temporal phylogeny and molecular characterization of echovirus 30 associated with aseptic meningitis outbreaks in China.
Virol J
; 18(1): 118, 2021 06 06.
Article
en En
| MEDLINE
| ID: mdl-34092258
ABSTRACT
BACKGROUND:
An outbreak of aseptic meningitis occurred from June to August 2016, in Inner Mongolia Autonomous Region, China.METHODS:
To determine its epidemiological characteristics, etiologic agent, and possible origin, specimens were collected for virus isolation and identification, followed by molecular epidemiological analysis.RESULTS:
A total of 363 patients were clinically diagnosed from June 1st to August 31st 2016, and most cases (63.1%, n = 229) were identified between June 22nd and July 17th, with children aged 6 to 12 years constituting the highest percentage (68.9%, n = 250). All viral isolates from this study belonged to genotype C of echovirus 30 (E30), which dominated transmission in China. To date, two E30 transmission lineages have been identified in China, of which Lineage 2 was predominant. We observed fluctuant progress of E30 genetic diversity, with Lineage 2 contributing to increased genetic diversity after 2002, whereas Lineage 1 was significant for the genetic diversity of E30 before 2002.CONCLUSIONS:
We identified the epidemiological and etiological causes of an aseptic meningitis outbreak in Inner Mongolia in 2016, and found that Lineage 2 played an important role in recent outbreaks. Moreover, we found that Gansu province could play an important role in E30 spread and might be a possible origin site. Furthermore, Fujian, Shandong, Taiwan, and Zhejiang provinces also demonstrated significant involvement in E30 evolution and persistence over time in China.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enterovirus Humano B
/
Infecciones por Echovirus
/
Meningitis Aséptica
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Child
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Virol J
Asunto de la revista:
VIROLOGIA
Año:
2021
Tipo del documento:
Article