Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of <i>MMP9</i> and <i>ABCG2</i>.

Huang, Ying; Yu, Shan-He; Zhen, Wen-Xuan; Cheng, Tao; Wang, Dan; Lin, Jie-Bo; Wu, Yu-Han; Wang, Yi-Fan; Chen, Yi; Shu, Li-Ping; Wang, Yi; Sun, Xiao-Jian; Zhou, Yi; Yang, Fan; Hsu, Chih-Hung; Xu, Peng-Fei

Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2.

Huang, Ying; Yu, Shan-He; Zhen, Wen-Xuan; Cheng, Tao; Wang, Dan; Lin, Jie-Bo; Wu, Yu-Han; Wang, Yi-Fan; Chen, Yi; Shu, Li-Ping; Wang, Yi; Sun, Xiao-Jian; Zhou, Yi; Yang, Fan; Hsu, Chih-Hung; Xu, Peng-Fei.

Afiliación

Huang Y; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yu SH; State Key Laboratory for Medical Genomics, National Research Center for Translational Medicine at Shanghai, Shanghai Institute of Hematology, Rui-Jin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Zhen WX; Department of biophysics and Kidney Disease Center of the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Cheng T; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Wang D; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Lin JB; Women's Hospital, and Institute of Genetics, and Department of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Wu YH; College of Pharmaceutical Sciences, Zhejiang University.
Wang YF; Zhejiang University-University of Edinburgh united Institute.
Chen Y; State Key Laboratory for Medical Genomics, National Research Center for Translational Medicine at Shanghai, Shanghai Institute of Hematology, Rui-Jin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Shu LP; Key Laboratory of Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, National & Guizhou Joint Engineering Laboratory for Cell Engineering and Biomedicine Technique, Guizhou Province Key Laboratory of Regenerative Medicine, Guizhou Medical University, Guiyang, Guizhou, C
Wang Y; College of Pharmaceutical Sciences, Zhejiang University.
Sun XJ; State Key Laboratory for Medical Genomics, National Research Center for Translational Medicine at Shanghai, Shanghai Institute of Hematology, Rui-Jin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Zhou Y; Harvard Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Yang F; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Pediatric Hematology/Oncology at Dana Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA.
Hsu CH; Department of biophysics and Kidney Disease Center of the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Xu PF; Women's Hospital, and Institute of Genetics, and Department of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou, China.

Theranostics ; 11(14): 6891-6904, 2021.

Article en En | MEDLINE | ID: mdl-34093860

Asunto(s)

Transportador de Casetes de Unión a ATP, Subfamilia G, Miembro 2/metabolismo; Abietanos/farmacología; Antineoplásicos Fitogénicos/farmacología; Proteína Potenciadora del Homólogo Zeste 2/antagonistas & inhibidores; Hematopoyesis/efectos de los fármacos; Leucemia/tratamiento farmacológico; Leucemia/metabolismo; Metaloproteinasa 9 de la Matriz/metabolismo; Proteínas de Neoplasias/metabolismo; Transportador de Casetes de Unión a ATP, Subfamilia G, Miembro 2/genética; Animales; Animales Modificados Genéticamente; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Proliferación Celular/genética; Inmunoprecipitación de Cromatina; Proteína Potenciadora del Homólogo Zeste 2/genética; Proteína Potenciadora del Homólogo Zeste 2/metabolismo; Perfilación de la Expresión Génica; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Regulación Neoplásica de la Expresión Génica/genética; Hematopoyesis/genética; Histonas/metabolismo; Humanos; Leucemia/enzimología; Leucemia/genética; Metaloproteinasa 9 de la Matriz/genética; Proteínas de Neoplasias/genética; Complejo Represivo Polycomb 2/metabolismo; Unión Proteica; RNA-Seq; Salvia miltiorrhiza/química; Resonancia por Plasmón de Superficie; Transcriptoma/genética; Ensayos Antitumor por Modelo de Xenoinjerto; Pez Cebra

Palabras clave

EZH2; H3K27me3; Tanshinone I; hematopoiesis; leukemia

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucemia / Metaloproteinasa 9 de la Matriz / Abietanos / Proteína Potenciadora del Homólogo Zeste 2 / Transportador de Casetes de Unión a ATP, Subfamilia G, Miembro 2 / Hematopoyesis / Proteínas de Neoplasias / Antineoplásicos Fitogénicos Límite: Animals / Humans Idioma: En Revista: Theranostics Año: 2021 Tipo del documento: Article País de afiliación: China

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