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Eicosanoid profiling in patients with complete form of pachydermoperiostosis carrying SLCO2A1 mutations.
Oiwa, Tomohiro; Ishibashi, Mami; Okuno, Toshiaki; Ohba, Mai; Endo, Yuichiro; Uozumi, Ryuji; Ghazawi, Feras M; Yoshida, Kazue; Niizeki, Hironori; Yokomizo, Takehiko; Nomura, Takashi; Kabashima, Kenji.
Afiliación
  • Oiwa T; Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Ishibashi M; Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Okuno T; Department of Dermatology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan.
  • Ohba M; Department of Biochemistry (I), Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Endo Y; Department of Biochemistry (I), Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Uozumi R; Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Ghazawi FM; Institute for Advancement of Clinical and Translational Science (iACT), Koto University Hospital, Kyoto, Japan.
  • Yoshida K; Division of Dermatology, University of Ottawa, Ottawa, Canada.
  • Niizeki H; Division of Dermatology, Department of Surgical Subspecialties, National Center for Child Health and Development, Tokyo, Japan.
  • Yokomizo T; Division of Dermatology, Department of Surgical Subspecialties, National Center for Child Health and Development, Tokyo, Japan.
  • Nomura T; Department of Biochemistry (I), Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Kabashima K; Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
J Dermatol ; 48(9): 1442-1446, 2021 Sep.
Article en En | MEDLINE | ID: mdl-34114674
ABSTRACT
Pachydermoperiostosis (PDP) is a genetic disease characterized by digital clubbing, periostosis, and pachydermia caused by mutated HPGD or SLCO2A1. Plasma prostaglandin (PG)E2 levels are increased in these patients. However, other eicosanoids have not been quantitated. We aimed to quantitate plasma eicosanoid levels in four patients carrying SLCO2A1 mutations by high-performance liquid chromatography-tandem mass spectrometry. PGE2 level was elevated in all patients; PGD2 and 11ß-PGF2 α levels were also increased in some patients, whereas eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid levels were decreased in all patients. Our data indicate a dysfunctional eicosanoid homeostasis and varied levels of PG in patients with a complete form of PDP carrying SLCO2A1 mutations. PGE2 levels seem to mostly affect the symptoms, with other eicosanoids possibly having a minor effect.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Osteoartropatía Hipertrófica Primaria / Transportadores de Anión Orgánico Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: J Dermatol Año: 2021 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
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Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Osteoartropatía Hipertrófica Primaria / Transportadores de Anión Orgánico Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: J Dermatol Año: 2021 Tipo del documento: Article País de afiliación: Japón