Kappa Opioid Receptor Mediated Differential Regulation of Serotonin and Dopamine Transporters in Mood and Substance Use Disorder.
Handb Exp Pharmacol
; 271: 97-112, 2022.
Article
en En
| MEDLINE
| ID: mdl-34136961
ABSTRACT
Dynorphin (DYN) is an endogenous neurosecretory peptide which exerts its activity by binding to the family of G protein-coupled receptors, namely the kappa opioid receptor (KOR). Opioids are associated with pain, analgesia, and drug abuse, which play a central role in mood disorders with monoamine neurotransmitter interactions. Growing evidence demonstrates the cellular signaling cascades linked to KOR-mediated monoamine transporters regulation in cell models and native brain tissues. This chapter will review DYN/KOR role in mood and addiction in relevance to dopaminergic and serotonergic neurotransmissions. Also, we discuss the recent findings on KOR-mediated differential regulation of serotonin and dopamine transporters (SERT and DAT). These findings led to a better understanding of the role of DYN/KOR system in aminergic neurotransmission via its modulatory effect on both amine release and clearance. Detailed knowledge of these processes at the molecular level enables designing novel pharmacological reagents to target transporter motifs to treat mood and addiction and reduce unwanted side effects such as aversion, dysphoria, sedation, and psychomimesis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Receptores Opioides kappa
/
Trastornos del Humor
/
Trastornos Relacionados con Sustancias
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Proteínas de Transporte de Dopamina a través de la Membrana Plasmática
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Proteínas de Transporte de Serotonina en la Membrana Plasmática
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Handb Exp Pharmacol
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos