Increased cytoplasmic expression of DLL4 is associated with favorable prognosis in colorectal cancer.
Future Oncol
; 17(24): 3231-3242, 2021 Aug.
Article
en En
| MEDLINE
| ID: mdl-34156260
ABSTRACT
Aims:
DLL4 of the Notch pathway is a key regulator of VEGF expression, which mediates tumor neovascularization and stem cell self-renewal in colorectal cancer (CRC). The authors investigated the association of DLL4 expression with the clinicopathological characteristics and survival outcomes of CRC patients.Methods:
DLL4 expression level was evaluated in 199 CRC samples using immunohistochemistry analysis of tissue microarrays.Results:
The high expression of DLL4 was inversely associated with distant metastasis (p < 0.029), tumor recurrence (p < 0.04) and longer overall survival following curative surgery compared with those with low DLL4 expression with 95% CI (log-rank test p = 0.050). In univariate analysis, histological grade (hazard ratio 3.859; 95% CI 1.081-13.784; p = 0.038) was a strong prognostic risk factor, affecting the overall survival of CRC patients.Conclusion:
The authors' results demonstrate that DLL4 expression might be considered a favorable prognostic factor for overall survival in CRC patients.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas de Unión al Calcio
/
Neoplasias Colorrectales
/
Biomarcadores de Tumor
/
Proteínas Adaptadoras Transductoras de Señales
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Future Oncol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Irán