Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids in Patients With Active Ulcerative Colitis (EXPECT Study): A Multicenter Prospective Clinical Trial.
Crohns Colitis 360
; 2(4): otaa073, 2020 Oct.
Article
en En
| MEDLINE
| ID: mdl-34192247
ABSTRACT
BACKGROUND:
Granulocyte and monocyte adsorptive apheresis (GMA) has been used for therapy of steroid-dependent/refractory ulcerative colitis (UC). The aim of this study was to investigate the effectiveness of GMA in UC patients not receiving steroids.METHODS:
We conducted a single-arm, open-label, and multicenter prospective clinical trial. UC patients who had insufficient responses to 5-aminosalicylic acid received GMA twice a week for 5 weeks.RESULTS:
The response rate of all patients was 58.2% (39/67). Of the 39 patients who achieved a response, 74.4% achieved endoscopically confirmed mucosal healing.CONCLUSIONS:
GMA shows effectiveness in inducing remission in UC patients not receiving steroid.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Tipo de estudio:
Clinical_trials
Idioma:
En
Revista:
Crohns Colitis 360
Año:
2020
Tipo del documento:
Article
País de afiliación:
Japón