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Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids in Patients With Active Ulcerative Colitis (EXPECT Study): A Multicenter Prospective Clinical Trial.
Kakimoto, Kazuki; Matsuura, Minoru; Fukuchi, Takumi; Hongo, Hitoshi; Kimura, Tsuguhiro; Aoyama, Nobuo; Okuda, Yorihide; Aomatsu, Kazuki; Kamata, Noriko; Yokoyama, Yoko; Mizuno, Chiemi; Inoue, Takuya; Miyazaki, Takako; Nakamura, Shiro; Higuchi, Kazuhide; Nakase, Hiroshi.
Afiliación
  • Kakimoto K; 2nd Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan.
  • Matsuura M; Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
  • Fukuchi T; Department of Gastroenterology and Hepatology, Iseikai Hospital, Osaka, Osaka, Japan.
  • Hongo H; Department of Gastroenterology, Fujita Gastroenterological Hospital, Takatsuki, Osaka, Japan.
  • Kimura T; Department of Gastroenterology, Fujita Gastroenterological Hospital, Takatsuki, Osaka, Japan.
  • Aoyama N; Department of Gastroenterology, Gastrointestinal Endoscopy and IBD Center, Aoyama Medical Clinic, Kobe, Hyogo, Japan.
  • Okuda Y; Department of Gastroenterology, Otemae Hospital, Osaka, Osaka, Japan.
  • Aomatsu K; Department of Gastroenterology, Izumiotsu Municipal Hospital, Izumiotsu, Osaka, Japan.
  • Kamata N; Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Osaka, Japan.
  • Yokoyama Y; Department of Intestinal Inflammation Research, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
  • Mizuno C; Department of Gastroenterology and Hepatology, Saiseikai Suita Hospital, Suita, Osaka, Japan.
  • Inoue T; 2nd Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan.
  • Miyazaki T; 2nd Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan.
  • Nakamura S; 2nd Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan.
  • Higuchi K; 2nd Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan.
  • Nakase H; Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
Crohns Colitis 360 ; 2(4): otaa073, 2020 Oct.
Article en En | MEDLINE | ID: mdl-34192247
ABSTRACT

BACKGROUND:

Granulocyte and monocyte adsorptive apheresis (GMA) has been used for therapy of steroid-dependent/refractory ulcerative colitis (UC). The aim of this study was to investigate the effectiveness of GMA in UC patients not receiving steroids.

METHODS:

We conducted a single-arm, open-label, and multicenter prospective clinical trial. UC patients who had insufficient responses to 5-aminosalicylic acid received GMA twice a week for 5 weeks.

RESULTS:

The response rate of all patients was 58.2% (39/67). Of the 39 patients who achieved a response, 74.4% achieved endoscopically confirmed mucosal healing.

CONCLUSIONS:

GMA shows effectiveness in inducing remission in UC patients not receiving steroid.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Crohns Colitis 360 Año: 2020 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Crohns Colitis 360 Año: 2020 Tipo del documento: Article País de afiliación: Japón