Difluoromethylornithine (DFMO), an Inhibitor of Polyamine Biosynthesis, and Antioxidant <i>N</i>-Acetylcysteine Potentiate Immune Response in Mice to the Recombinant Hepatitis C Virus NS5B Protein.

Lesnova, Ekaterina I; Masalova, Olga V; Permyakova, Kristina Yu; Kozlov, Vyacheslav V; Nikolaeva, Tatyana N; Pronin, Alexander V; Valuev-Elliston, Vladimir T; Ivanov, Alexander V; Kushch, Alla A

Difluoromethylornithine (DFMO), an Inhibitor of Polyamine Biosynthesis, and Antioxidant N-Acetylcysteine Potentiate Immune Response in Mice to the Recombinant Hepatitis C Virus NS5B Protein.

Lesnova, Ekaterina I; Masalova, Olga V; Permyakova, Kristina Yu; Kozlov, Vyacheslav V; Nikolaeva, Tatyana N; Pronin, Alexander V; Valuev-Elliston, Vladimir T; Ivanov, Alexander V; Kushch, Alla A.

Afiliación

Lesnova EI; Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Masalova OV; Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Permyakova KY; Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Kozlov VV; Federal State Budgetary Educational Institution of Higher Education "Moscow State Academy of Veterinary Medicine and Biotechnology-MVA by K.I. Skryabin", 109472 Moscow, Russia.
Nikolaeva TN; Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Pronin AV; Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Valuev-Elliston VT; Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Ivanov AV; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Kushch AA; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.

Int J Mol Sci ; 22(13)2021 Jun 26.

Article en En | MEDLINE | ID: mdl-34206987

Asunto(s)

Acetilcisteína/farmacología; Adyuvantes Inmunológicos/farmacología; Eflornitina/farmacología; Hepatitis C/inmunología; Inmunidad Activa/efectos de los fármacos; Proteínas no Estructurales Virales/inmunología; Animales; Proliferación Celular; Células Cultivadas; Femenino; Inmunogenicidad Vacunal/efectos de los fármacos; Interferón gamma/metabolismo; Interleucina-10/metabolismo; Interleucina-12/metabolismo; Ratones; Ratones Endogámicos DBA; Células Supresoras de Origen Mieloide/efectos de los fármacos; Células Supresoras de Origen Mieloide/inmunología; Óxido Nítrico/metabolismo; Oligodesoxirribonucleótidos/farmacología; Linfocitos T Reguladores/efectos de los fármacos; Linfocitos T Reguladores/inmunología; Vacunas contra Hepatitis Viral/inmunología

Palabras clave

CpG ODN 1826; HCV vaccine; N-acetylcysteine (NAC); adjuvants; difluoromethylornithine (DFMO); hepatitis C virus (HCV); immune response; myeloid-derived suppressor cells (MDSC); nonstructural protein NS5B; regulatory T cells (Treg)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Acetilcisteína / Adyuvantes Inmunológicos / Eflornitina / Hepatitis C / Proteínas no Estructurales Virales / Inmunidad Activa Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Rusia

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