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Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity.
Akbari, Parsa; Gilani, Ankit; Sosina, Olukayode; Kosmicki, Jack A; Khrimian, Lori; Fang, Yi-Ya; Persaud, Trikaldarshi; Garcia, Victor; Sun, Dylan; Li, Alexander; Mbatchou, Joelle; Locke, Adam E; Benner, Christian; Verweij, Niek; Lin, Nan; Hossain, Sakib; Agostinucci, Kevin; Pascale, Jonathan V; Dirice, Ercument; Dunn, Michael; Kraus, William E; Shah, Svati H; Chen, Yii-Der I; Rotter, Jerome I; Rader, Daniel J; Melander, Olle; Still, Christopher D; Mirshahi, Tooraj; Carey, David J; Berumen-Campos, Jaime; Kuri-Morales, Pablo; Alegre-Díaz, Jesus; Torres, Jason M; Emberson, Jonathan R; Collins, Rory; Balasubramanian, Suganthi; Hawes, Alicia; Jones, Marcus; Zambrowicz, Brian; Murphy, Andrew J; Paulding, Charles; Coppola, Giovanni; Overton, John D; Reid, Jeffrey G; Shuldiner, Alan R; Cantor, Michael; Kang, Hyun M; Abecasis, Goncalo R; Karalis, Katia; Economides, Aris N.
Afiliación
  • Akbari P; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Gilani A; Department of Pharmacology and Medicine, New York Medical College School of Medicine, Valhalla, NY 10595, USA.
  • Sosina O; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Kosmicki JA; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Khrimian L; Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Fang YY; Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Persaud T; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Garcia V; Department of Pharmacology and Medicine, New York Medical College School of Medicine, Valhalla, NY 10595, USA.
  • Sun D; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Li A; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Mbatchou J; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Locke AE; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Benner C; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Verweij N; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Lin N; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Hossain S; Department of Pharmacology and Medicine, New York Medical College School of Medicine, Valhalla, NY 10595, USA.
  • Agostinucci K; Department of Pharmacology and Medicine, New York Medical College School of Medicine, Valhalla, NY 10595, USA.
  • Pascale JV; Department of Pharmacology and Medicine, New York Medical College School of Medicine, Valhalla, NY 10595, USA.
  • Dirice E; Department of Pharmacology and Medicine, New York Medical College School of Medicine, Valhalla, NY 10595, USA.
  • Dunn M; Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Kraus WE; Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA.
  • Shah SH; Duke Center for Living, Duke University Medical Center, Durham, NC 27705, USA.
  • Chen YI; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  • Rotter JI; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27701, USA.
  • Rader DJ; Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation, and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
  • Melander O; Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation, and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
  • Still CD; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.
  • Mirshahi T; Department of Clinical Sciences Malmö, Lund University, 221 00 Malmö, Sweden.
  • Carey DJ; Department of Emergency and Internal Medicine, Skåne University Hospital, 214 28, Malmö, Sweden.
  • Berumen-Campos J; Geisinger Obesity Institute, Geisinger Health System, Danville, PA 17882, USA.
  • Kuri-Morales P; Geisinger Obesity Institute, Geisinger Health System, Danville, PA 17882, USA.
  • Alegre-Díaz J; Geisinger Obesity Institute, Geisinger Health System, Danville, PA 17882, USA.
  • Torres JM; Faculty of Medicine, National Autonomous University of Mexico, Copilco Universidad, Coyoacán, 4360 Ciudad de México, Mexico.
  • Emberson JR; Faculty of Medicine, National Autonomous University of Mexico, Copilco Universidad, Coyoacán, 4360 Ciudad de México, Mexico.
  • Collins R; Faculty of Medicine, National Autonomous University of Mexico, Copilco Universidad, Coyoacán, 4360 Ciudad de México, Mexico.
  • Balasubramanian S; Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, England, UK.
  • Hawes A; Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, England, UK.
  • Jones M; Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, England, UK.
  • Zambrowicz B; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Murphy AJ; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Paulding C; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Coppola G; Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Overton JD; Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Reid JG; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Shuldiner AR; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Cantor M; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Kang HM; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Abecasis GR; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Karalis K; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
  • Economides AN; Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
Science ; 373(6550)2021 07 02.
Article en En | MEDLINE | ID: mdl-34210852
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Índice de Masa Corporal / Receptores Acoplados a Proteínas G / Exoma / Obesidad Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Science Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Índice de Masa Corporal / Receptores Acoplados a Proteínas G / Exoma / Obesidad Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Science Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos