Infiltration by CXCL10 Secreting Macrophages Is Associated With Antitumor Immunity and Response to Therapy in Ovarian Cancer Subtypes.

Ardighieri, Laura; Missale, Francesco; Bugatti, Mattia; Gatta, Luisa Benerini; Pezzali, Irene; Monti, Matilde; Gottardi, Stefano; Zanotti, Laura; Bignotti, Eliana; Ravaggi, Antonella; Tognon, Germana; Odicino, Franco; Calza, Stefano; Missolo-Koussou, Yoann; Ries, Carola Hermine; Helft, Julie; Vermi, William

Ardighieri, Laura; Missale, Francesco; Bugatti, Mattia; Gatta, Luisa Benerini; Pezzali, Irene; Monti, Matilde; Gottardi, Stefano; Zanotti, Laura; Bignotti, Eliana; Ravaggi, Antonella; Tognon, Germana; Odicino, Franco; Calza, Stefano; Missolo-Koussou, Yoann; Ries, Carola Hermine; Helft, Julie; Vermi, William.

Afiliación

Ardighieri L; Unit of Pathology, ASST Spedali Civili di Brescia, Brescia, Italy.
Missale F; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Bugatti M; IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Gatta LB; Unit of Pathology, ASST Spedali Civili di Brescia, Brescia, Italy.
Pezzali I; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Monti M; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Gottardi S; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Zanotti L; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Bignotti E; Diatech Pharmacogenetics srl, Jesi, Italy.
Ravaggi A; 'Angelo Nocivelli" Institute of Molecular Medicine, ASST Spedali Civili of Brescia- University of Brescia, Brescia, Italy.
Tognon G; Division of Obstetrics and Gynecology, ASST Spedali Civili di Brescia, Brescia, Italy.
Odicino F; 'Angelo Nocivelli" Institute of Molecular Medicine, ASST Spedali Civili of Brescia- University of Brescia, Brescia, Italy.
Calza S; Division of Obstetrics and Gynecology, ASST Spedali Civili di Brescia, Brescia, Italy.
Missolo-Koussou Y; 'Angelo Nocivelli" Institute of Molecular Medicine, ASST Spedali Civili of Brescia- University of Brescia, Brescia, Italy.
Ries CH; Division of Obstetrics and Gynecology, ASST Spedali Civili di Brescia, Brescia, Italy.
Helft J; Department of Clinical and Experimental Science, University of Brescia, Brescia, Italy.
Vermi W; Division of Obstetrics and Gynecology, ASST Spedali Civili di Brescia, Brescia, Italy.

Front Immunol ; 12: 690201, 2021.

Article en En | MEDLINE | ID: mdl-34220848

Asunto(s)

Carcinoma/metabolismo; Quimiocina CXCL10/metabolismo; Linfocitos Infiltrantes de Tumor/metabolismo; Neoplasias Quísticas, Mucinosas y Serosas/metabolismo; Neoplasias Ováricas/metabolismo; Microambiente Tumoral; Macrófagos Asociados a Tumores/metabolismo; Anciano; Antígenos CD/metabolismo; Antígenos de Diferenciación Mielomonocítica/metabolismo; Complejo CD3/metabolismo; Carcinoma/tratamiento farmacológico; Carcinoma/genética; Carcinoma/inmunología; Células Cultivadas; Quimiocina CXCL10/genética; Resistencia a Antineoplásicos; Femenino; Humanos; Factor 1 Regulador del Interferón/genética; Factor 1 Regulador del Interferón/metabolismo; Linfocitos Infiltrantes de Tumor/inmunología; Glicoproteínas de Membrana/genética; Glicoproteínas de Membrana/metabolismo; Persona de Mediana Edad; Neoplasias Quísticas, Mucinosas y Serosas/tratamiento farmacológico; Neoplasias Quísticas, Mucinosas y Serosas/genética; Neoplasias Quísticas, Mucinosas y Serosas/inmunología; Neoplasias Ováricas/tratamiento farmacológico; Neoplasias Ováricas/genética; Neoplasias Ováricas/inmunología; Fenotipo; Pronóstico; Receptores de Superficie Celular/metabolismo; Receptores Inmunológicos/genética; Receptores Inmunológicos/metabolismo; Factor de Transcripción STAT1/genética; Factor de Transcripción STAT1/metabolismo; Macrófagos Asociados a Tumores/inmunología

Palabras clave

CXCL10; macrophage; ovarian cancer; polarization; signature

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Carcinoma / Linfocitos Infiltrantes de Tumor / Neoplasias Quísticas, Mucinosas y Serosas / Quimiocina CXCL10 / Microambiente Tumoral / Macrófagos Asociados a Tumores Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Immunol Año: 2021 Tipo del documento: Article País de afiliación: Italia

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