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Factors associated with serum IgM concentrations: a general adult population study.
Carballo, Iago; Alonso-Sampedro, Manuela; Escribano, Rosa-María; Fernandez-Merino, Carmen; Sopeña, Bernardo; Vidal, Carmen; Gude, Francisco; Gonzalez-Quintela, Arturo.
Afiliación
  • Carballo I; Department of Internal Medicine, University Hospital of Santiago, University of Santiago de Compostela, Santiago de Compostela, Spain.
  • Alonso-Sampedro M; Immunology, Cancer and GlycoMedicine, Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal.
  • Escribano RM; Department of Clinical Epidemiology, University Hospital of Santiago, Santiago de Compostela, Spain.
  • Fernandez-Merino C; Department of Internal Medicine, University Hospital of Santiago, University of Santiago de Compostela, Santiago de Compostela, Spain.
  • Sopeña B; Primary Care Center, A Estrada, Spain.
  • Vidal C; Department of Internal Medicine, University Hospital of Santiago, University of Santiago de Compostela, Santiago de Compostela, Spain.
  • Gude F; Department of Allergy, University Hospital of Santiago, University of Santiago de Compostela, Santiago de Compostela, Spain.
  • Gonzalez-Quintela A; Department of Clinical Epidemiology, University Hospital of Santiago, Santiago de Compostela, Spain.
Scand J Clin Lab Invest ; 81(6): 454-460, 2021 Oct.
Article en En | MEDLINE | ID: mdl-34236241
BACKGROUND AND AIM: To investigate the influence of common factors on serum immunoglobulin M (IgM) concentrations in adults, and clinical associations with high and low values. METHODS: We measured serum IgM levels using immunonephelometry in a random sample of 1510 individuals (aged 18-91 years, 44.7% male). We obtained data defining metabolic syndrome from all participants, defined atopy by skin prick tests to aeroallergens, and assessed lifestyle factors by questionnaire. RESULTS: Women showed higher IgM concentrations than men; 95 (6.3%, mostly male) individuals showed low (<0.40 g/L) IgM values, and 64 (4.2%, mostly female) showed high (>2.30 g/L) IgM values. Individuals with abnormal IgM concentrations had no history of opportunistic infections nor a different atopy prevalence. Serum IgM concentrations decreased with age, and obesity was negatively associated with IgM concentrations. Alcohol consumption, smoking, physical activity, and metabolic syndrome had no significant influence in the multivariate analyses. CONCLUSIONS: Many adults in the general population show abnormally high or low IgM concentrations with no evidence of immunodeficiency-associated diseases. Sex and age should be considered when defining reference IgM concentrations.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inmunoglobulina M Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Scand J Clin Lab Invest Año: 2021 Tipo del documento: Article País de afiliación: España

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inmunoglobulina M Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Scand J Clin Lab Invest Año: 2021 Tipo del documento: Article País de afiliación: España