The 2021 update of the EPA's adverse outcome pathway database.
Sci Data
; 8(1): 169, 2021 07 12.
Article
en En
| MEDLINE
| ID: mdl-34253739
ABSTRACT
The EPA developed the Adverse Outcome Pathway Database (AOP-DB) to better characterize adverse outcomes of toxicological interest that are relevant to human health and the environment. Here we present the most recent version of the EPA Adverse Outcome Pathway Database (AOP-DB), version 2. AOP-DB v.2 introduces several substantial updates, which include automated data pulls from the AOP-Wiki 2.0, the integration of tissue-gene network data, and human AOP-gene data by population, semantic mapping and SPARQL endpoint creation, in addition to the presentation of the first publicly available AOP-DB web user interface. Potential users of the data may investigate specific molecular targets of an AOP, the relation of those gene/protein targets to other AOPs, cross-species, pathway, or disease-AOP relationships, or frequencies of AOP-related functional variants in particular populations, for example. Version updates described herein help inform new testable hypotheses about the etiology and mechanisms underlying adverse outcomes of environmental and toxicological concern.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
United States Environmental Protection Agency
/
Bases de Datos Factuales
/
Rutas de Resultados Adversos
Límite:
Humans
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Sci Data
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos