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Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe.
Yushkevich, Paul A; Muñoz López, Mónica; Iñiguez de Onzoño Martin, María Mercedes; Ittyerah, Ranjit; Lim, Sydney; Ravikumar, Sadhana; Bedard, Madigan L; Pickup, Stephen; Liu, Weixia; Wang, Jiancong; Hung, Ling Yu; Lasserve, Jade; Vergnet, Nicolas; Xie, Long; Dong, Mengjin; Cui, Salena; McCollum, Lauren; Robinson, John L; Schuck, Theresa; de Flores, Robin; Grossman, Murray; Tisdall, M Dylan; Prabhakaran, Karthik; Mizsei, Gabor; Das, Sandhitsu R; Artacho-Pérula, Emilio; Arroyo Jiménez, Mari'a Del Mar; Marcos Raba, Mari'a Pilar; Molina Romero, Francisco Javier; Cebada Sánchez, Sandra; Delgado González, José Carlos; de la Rosa-Prieto, Carlos; Córcoles Parada, Marta; Lee, Edward B; Trojanowski, John Q; Ohm, Daniel T; Wisse, Laura E M; Wolk, David A; Irwin, David J; Insausti, Ricardo.
Afiliación
  • Yushkevich PA; Department of Radiology, University of Pennsylvania, Philadelphia, USA.
  • Muñoz López M; Human Neuroanatomy Laboratory, Neuromax CSIC Associated Unit, University of Castilla-La Mancha, Albacete, Spain.
  • Iñiguez de Onzoño Martin MM; Human Neuroanatomy Laboratory, Neuromax CSIC Associated Unit, University of Castilla-La Mancha, Albacete, Spain.
  • Ittyerah R; Department of Radiology, University of Pennsylvania, Philadelphia, USA.
  • Lim S; Department of Radiology, University of Pennsylvania, Philadelphia, USA.
  • Ravikumar S; Department of Radiology, University of Pennsylvania, Philadelphia, USA.
  • Bedard ML; Department of Radiology, University of Pennsylvania, Philadelphia, USA.
  • Pickup S; Department of Radiology, University of Pennsylvania, Philadelphia, USA.
  • Liu W; Department of Radiology, University of Pennsylvania, Philadelphia, USA.
  • Wang J; Department of Radiology, University of Pennsylvania, Philadelphia, USA.
  • Hung LY; Department of Radiology, University of Pennsylvania, Philadelphia, USA.
  • Lasserve J; Department of Radiology, University of Pennsylvania, Philadelphia, USA.
  • Vergnet N; Department of Radiology, University of Pennsylvania, Philadelphia, USA.
  • Xie L; Department of Radiology, University of Pennsylvania, Philadelphia, USA.
  • Dong M; Department of Radiology, University of Pennsylvania, Philadelphia, USA.
  • Cui S; Department of Neurology, University of Pennsylvania, Philadelphia, USA.
  • McCollum L; Department of Neurology, University of Pennsylvania, Philadelphia, USA.
  • Robinson JL; Department of Pathology, University of Pennsylvania, Philadelphia, USA.
  • Schuck T; Department of Pathology, University of Pennsylvania, Philadelphia, USA.
  • de Flores R; Institut National de la Santé et de la Recherche Médicale (INSERM), Caen, France.
  • Grossman M; Department of Neurology, University of Pennsylvania, Philadelphia, USA.
  • Tisdall MD; Department of Radiology, University of Pennsylvania, Philadelphia, USA.
  • Prabhakaran K; Department of Neurology, University of Pennsylvania, Philadelphia, USA.
  • Mizsei G; Department of Radiology, University of Pennsylvania, Philadelphia, USA.
  • Das SR; Department of Neurology, University of Pennsylvania, Philadelphia, USA.
  • Artacho-Pérula E; Human Neuroanatomy Laboratory, Neuromax CSIC Associated Unit, University of Castilla-La Mancha, Albacete, Spain.
  • Arroyo Jiménez MDM; Human Neuroanatomy Laboratory, Neuromax CSIC Associated Unit, University of Castilla-La Mancha, Albacete, Spain.
  • Marcos Raba MP; Human Neuroanatomy Laboratory, Neuromax CSIC Associated Unit, University of Castilla-La Mancha, Albacete, Spain.
  • Molina Romero FJ; Human Neuroanatomy Laboratory, Neuromax CSIC Associated Unit, University of Castilla-La Mancha, Albacete, Spain.
  • Cebada Sánchez S; Human Neuroanatomy Laboratory, Neuromax CSIC Associated Unit, University of Castilla-La Mancha, Albacete, Spain.
  • Delgado González JC; Human Neuroanatomy Laboratory, Neuromax CSIC Associated Unit, University of Castilla-La Mancha, Albacete, Spain.
  • de la Rosa-Prieto C; Human Neuroanatomy Laboratory, Neuromax CSIC Associated Unit, University of Castilla-La Mancha, Albacete, Spain.
  • Córcoles Parada M; Human Neuroanatomy Laboratory, Neuromax CSIC Associated Unit, University of Castilla-La Mancha, Albacete, Spain.
  • Lee EB; Department of Pathology, University of Pennsylvania, Philadelphia, USA.
  • Trojanowski JQ; Department of Pathology, University of Pennsylvania, Philadelphia, USA.
  • Ohm DT; Department of Neurology, University of Pennsylvania, Philadelphia, USA.
  • Wisse LEM; Department of Diagnostic Radiology, University of Lund, Lund, Sweden.
  • Wolk DA; Department of Neurology, University of Pennsylvania, Philadelphia, USA.
  • Irwin DJ; Department of Neurology, University of Pennsylvania, Philadelphia, USA.
  • Insausti R; Human Neuroanatomy Laboratory, Neuromax CSIC Associated Unit, University of Castilla-La Mancha, Albacete, Spain.
Brain ; 144(9): 2784-2797, 2021 10 22.
Article en En | MEDLINE | ID: mdl-34259858
ABSTRACT
Tau protein neurofibrillary tangles are closely linked to neuronal/synaptic loss and cognitive decline in Alzheimer's disease and related dementias. Our knowledge of the pattern of neurofibrillary tangle progression in the human brain, critical to the development of imaging biomarkers and interpretation of in vivo imaging studies in Alzheimer's disease, is based on conventional two-dimensional histology studies that only sample the brain sparsely. To address this limitation, ex vivo MRI and dense serial histological imaging in 18 human medial temporal lobe specimens (age 75.3 ± 11.4 years, range 45 to 93) were used to construct three-dimensional quantitative maps of neurofibrillary tangle burden in the medial temporal lobe at individual and group levels. Group-level maps were obtained in the space of an in vivo brain template, and neurofibrillary tangles were measured in specific anatomical regions defined in this template. Three-dimensional maps of neurofibrillary tangle burden revealed significant variation along the anterior-posterior axis. While early neurofibrillary tangle pathology is thought to be confined to the transentorhinal region, we found similar levels of burden in this region and other medial temporal lobe subregions, including amygdala, temporopolar cortex, and subiculum/cornu ammonis 1 hippocampal subfields. Overall, the three-dimensional maps of neurofibrillary tangle burden presented here provide more complete information about the distribution of this neurodegenerative pathology in the region of the cortex where it first emerges in Alzheimer's disease, and may help inform the field about the patterns of pathology spread, as well as support development and validation of neuroimaging biomarkers.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Lóbulo Temporal / Mapeo Encefálico / Ovillos Neurofibrilares / Imagenología Tridimensional Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Brain Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Lóbulo Temporal / Mapeo Encefálico / Ovillos Neurofibrilares / Imagenología Tridimensional Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Brain Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos