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Evaluation of peripherin in biofluids of patients with motor neuron diseases.
Sabbatini, Daniele; Raggi, Flavia; Ruggero, Susanna; Seguso, Mara; Mandrioli, Jessica; Cagnin, Annachiara; Briani, Chiara; Toffanin, Elisabetta; Gizzi, Matteo; Fortuna, Andrea; Bello, Luca; Pegoraro, Elena; Musso, Giulia; Sorarù, Gianni.
Afiliación
  • Sabbatini D; Department of Neurosciences, University of Padova, Padova, Italy.
  • Raggi F; Department of Neurosciences, University of Padova, Padova, Italy.
  • Ruggero S; Department of Neurosciences, General Hospital of Padua, Padova, Italy.
  • Seguso M; Department of Neurosciences, University of Padova, Padova, Italy.
  • Mandrioli J; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, 41125, Italy.
  • Cagnin A; Department of Neurosciences, Azienda Ospedaliera Universitaria Modena, Modena, 41126, Italy.
  • Briani C; Department of Neurosciences, University of Padova, Padova, Italy.
  • Toffanin E; Department of Neurosciences, University of Padova, Padova, Italy.
  • Gizzi M; Department of Neurosciences, General Hospital of Padua, Padova, Italy.
  • Fortuna A; Department of Neurosciences, University of Padova, Padova, Italy.
  • Bello L; Department of Neurosciences, University of Padova, Padova, Italy.
  • Pegoraro E; Department of Neurosciences, University of Padova, Padova, Italy.
  • Musso G; Department of Neurosciences, University of Padova, Padova, Italy.
  • Sorarù G; Department of Laboratory Medicine, University of Padova, Padova, Italy.
Ann Clin Transl Neurol ; 8(8): 1750-1754, 2021 08.
Article en En | MEDLINE | ID: mdl-34264016
Peripherin (PRPH), a type III intermediate filament, assembles with neurofilaments in neurons of the peripheral nervous system, including lower motor neurons (LMN). To evaluate the role of PRPH in LMN degeneration, we assessed PRPH and neurofilament light chain (NfL) in cerebrospinal fluid (CSF) and serum of 91 patients with motor neuron diseases (MND) and 69 controls. Overall, we found PRPH to be more concentrated in serum than in CSF. Serum PRPH resulted significantly increased in MND patients but it was unrelated to CSF-NfL or survival in the amyotrophic lateral sclerosis (ALS) subset. PRPH might represent a marker of LMN involvement.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas de Neurofilamentos / Enfermedad de la Neurona Motora / Periferinas Tipo de estudio: Observational_studies Límite: Humans Idioma: En Revista: Ann Clin Transl Neurol Año: 2021 Tipo del documento: Article País de afiliación: Italia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas de Neurofilamentos / Enfermedad de la Neurona Motora / Periferinas Tipo de estudio: Observational_studies Límite: Humans Idioma: En Revista: Ann Clin Transl Neurol Año: 2021 Tipo del documento: Article País de afiliación: Italia