Porcine Circovirus 2 Manipulates the PERK-ERO1&#945; Axis of the Endoplasmic Reticulum To Favor Its Replication by Derepressing Viral DNA from HMGB1 Sequestration within Nuclei.

Sun, Renjie; Deng, Zhuofan; Han, Xiao; Zhang, Yikai; Zhou, Yingshan; Shan, Ying; Fang, Weihuan; Li, Xiaoliang

Porcine Circovirus 2 Manipulates the PERK-ERO1α Axis of the Endoplasmic Reticulum To Favor Its Replication by Derepressing Viral DNA from HMGB1 Sequestration within Nuclei.

Sun, Renjie; Deng, Zhuofan; Han, Xiao; Zhang, Yikai; Zhou, Yingshan; Shan, Ying; Fang, Weihuan; Li, Xiaoliang.

Afiliación

Sun R; Institute of Preventive Veterinary Medicine and Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang Universitygrid.13402.34, Hangzhou, Zhejiang, China.
Deng Z; Institute of Preventive Veterinary Medicine and Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang Universitygrid.13402.34, Hangzhou, Zhejiang, China.
Han X; Institute of Preventive Veterinary Medicine and Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang Universitygrid.13402.34, Hangzhou, Zhejiang, China.
Zhang Y; Institute of Preventive Veterinary Medicine and Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang Universitygrid.13402.34, Hangzhou, Zhejiang, China.
Zhou Y; The 2nd Affiliated Hospital, School of Medicine, Zhejiang Universitygrid.13402.34, Hangzhou, Zhejiang, China.
Shan Y; College of Veterinary Medicine, Zhejiang A&F University, Hangzhou, Zhejiang, China.
Fang W; Institute of Preventive Veterinary Medicine and Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang Universitygrid.13402.34, Hangzhou, Zhejiang, China.
Li X; Institute of Preventive Veterinary Medicine and Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang Universitygrid.13402.34, Hangzhou, Zhejiang, China.

J Virol ; 95(19): e0100921, 2021 09 09.

Article en En | MEDLINE | ID: mdl-34287039

Asunto(s)

Núcleo Celular/metabolismo; Circovirus/fisiología; ADN Viral/metabolismo; Retículo Endoplásmico/metabolismo; Proteína HMGB1/metabolismo; Oxidorreductasas/metabolismo; eIF-2 Quinasa/metabolismo; Animales; Proteínas de la Cápside/química; Proteínas de la Cápside/metabolismo; Línea Celular; Cisteína/metabolismo; Replicación del ADN; Activación Enzimática; Especies Reactivas de Oxígeno/metabolismo; Porcinos; Regulación hacia Arriba; Proteínas Virales/metabolismo; Replicación Viral

Palabras clave

endoplasmic reticulum stress; high-mobility group box 1 protein; oxidative stress; porcine circovirus type 2; viral replication

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oxidorreductasas / ADN Viral / Núcleo Celular / Circovirus / EIF-2 Quinasa / Proteína HMGB1 / Retículo Endoplásmico Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Virol Año: 2021 Tipo del documento: Article País de afiliación: China

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