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Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model.
Xu, Xiaoyan; Sun, Yaqin; Cen, Xufeng; Shan, Bing; Zhao, Qingwei; Xie, Tingxue; Wang, Zhe; Hou, Tingjun; Xue, Yu; Zhang, Mengmeng; Peng, Di; Sun, Qiming; Yi, Cong; Najafov, Ayaz; Xia, Hongguang.
Afiliación
  • Xu X; Department of Biochemistry & Research Center of Clinical Pharmacy of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
  • Sun Y; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, China.
  • Cen X; Department of Biochemistry & Research Center of Clinical Pharmacy of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
  • Shan B; Department of Biochemistry & Research Center of Clinical Pharmacy of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
  • Zhao Q; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Xie T; Department of Biochemistry & Research Center of Clinical Pharmacy of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
  • Wang Z; Department of Biochemistry & Research Center of Clinical Pharmacy of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
  • Hou T; College of Pharmaceutical Sciences, Hangzhou Institute of innovative Medicine, Zhejiang University, Hangzhou, 310058, China.
  • Xue Y; College of Pharmaceutical Sciences, Hangzhou Institute of innovative Medicine, Zhejiang University, Hangzhou, 310058, China.
  • Zhang M; Key Laboratory of Molecular Biophysics of Ministry of Education, Hubei Bioinformatics and Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
  • Peng D; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Sun Q; Key Laboratory of Molecular Biophysics of Ministry of Education, Hubei Bioinformatics and Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
  • Yi C; Department of Biochemistry & Research Center of Clinical Pharmacy of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
  • Najafov A; Department of Biochemistry & Research Center of Clinical Pharmacy of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
  • Xia H; Department of Cell Biology, Harvard Medical School, Boston, MA, 02115, USA. najafov@gmail.com.
Protein Cell ; 12(10): 769-787, 2021 10.
Article en En | MEDLINE | ID: mdl-34291435
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Precursor de Proteína beta-Amiloide / Fármacos Neuroprotectores / Quinasas Quinasa Quinasa PAM / Proteínas del Choque Térmico HSC70 / Enfermedad de Alzheimer / Autofagia Mediada por Chaperones / Metformina Límite: Animals / Humans / Male Idioma: En Revista: Protein Cell Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Precursor de Proteína beta-Amiloide / Fármacos Neuroprotectores / Quinasas Quinasa Quinasa PAM / Proteínas del Choque Térmico HSC70 / Enfermedad de Alzheimer / Autofagia Mediada por Chaperones / Metformina Límite: Animals / Humans / Male Idioma: En Revista: Protein Cell Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China