Quantitative HPLC-MS/MS determination of Nuc, the active metabolite of remdesivir, and its pharmacokinetics in rat.

Du, Ping; Wang, Guoyong; Yang, Song; Li, Pengfei; Liu, Lihong

Du, Ping; Wang, Guoyong; Yang, Song; Li, Pengfei; Liu, Lihong.

Afiliación

Du P; Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, No.8 Gongti South Road, Chaoyang District, Beijing, 100020, People's Republic of China. pingdu2012@163.com.
Wang G; Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, No.8 Gongti South Road, Chaoyang District, Beijing, 100020, People's Republic of China.
Yang S; Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, No.8 Gongti South Road, Chaoyang District, Beijing, 100020, People's Republic of China.
Li P; Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, No.8 Gongti South Road, Chaoyang District, Beijing, 100020, People's Republic of China.
Liu L; Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, No.8 Gongti South Road, Chaoyang District, Beijing, 100020, People's Republic of China. liulihong@bjcyh.com.

Anal Bioanal Chem ; 413(23): 5811-5820, 2021 Sep.

Article en En | MEDLINE | ID: mdl-34302183

Asunto(s)

Adenosina Monofosfato/análogos & derivados; Adenosina/análogos & derivados; Alanina/análogos & derivados; Antivirales/sangre; Cromatografía Líquida de Alta Presión/métodos; Espectrometría de Masas en Tándem/métodos; Adenosina/sangre; Adenosina/farmacocinética; Adenosina/normas; Adenosina Monofosfato/sangre; Adenosina Monofosfato/farmacocinética; Adenosina Monofosfato/normas; Alanina/sangre; Alanina/farmacocinética; Alanina/normas; Animales; Antivirales/farmacocinética; Antivirales/normas; Límite de Detección; Masculino; Control de Calidad; Ratas; Ratas Sprague-Dawley; Estándares de Referencia; Reproducibilidad de los Resultados

Palabras clave

HPLC-MS/MS; Nuc; Pharmacokinetics; Quantitation; Remdesivir

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antivirales / Adenosina / Adenosina Monofosfato / Cromatografía Líquida de Alta Presión / Alanina / Espectrometría de Masas en Tándem Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: Anal Bioanal Chem Año: 2021 Tipo del documento: Article

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