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Phenotypic/Genotypic Profile of OXA-10-Like-Harboring, Carbapenem-Resistant Pseudomonas aeruginosa: Using Validated Pharmacokinetic/Pharmacodynamic In Vivo Models To Further Evaluate Enzyme Functionality and Clinical Implications.
Gill, Christian M; Brink, Adrian; Chu, Chun Yat; Coetzee, Jennifer; Dimopoulos, George; Moodley, Clinton; Opperman, Christoffel Johannes; Pournaras, Spyros; Tenover, Fred C; Tickler, Isabella A; Tootla, Hafsah Deepa; Vourli, Sophia; Nicolau, David P.
Afiliación
  • Gill CM; Center for Anti-Infective Research and Development, Hartford Hospitalgrid.277313.3, Hartford, Connecticut, USA.
  • Brink A; Division of Medical Microbiology, Department of Pathology, Faculty of Health Sciences, National Health Laboratory Services, University of Cape Town, Cape Town, South Africa.
  • Chu CY; Division of Medical Microbiology, Department of Pathology, Faculty of Health Sciences, National Health Laboratory Services, University of Cape Town, Cape Town, South Africa.
  • Coetzee J; Department of Medical Microbiology, Ampath National Reference Laboratory, Centurion, Pretoria, South Africa.
  • Dimopoulos G; Department of Critical Care Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
  • Moodley C; Division of Medical Microbiology, Department of Pathology, Faculty of Health Sciences, National Health Laboratory Services, University of Cape Town, Cape Town, South Africa.
  • Opperman CJ; Division of Medical Microbiology, Department of Pathology, Faculty of Health Sciences, National Health Laboratory Services, University of Cape Town, Cape Town, South Africa.
  • Pournaras S; Laboratory of Clinical Microbiology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
  • Tenover FC; Cepheid, Sunnyvale, California, USA.
  • Tickler IA; Cepheid, Sunnyvale, California, USA.
  • Tootla HD; Division of Medical Microbiology, Department of Pathology, Faculty of Health Sciences, National Health Laboratory Services, University of Cape Town, Cape Town, South Africa.
  • Vourli S; Laboratory of Clinical Microbiology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
  • Nicolau DP; Center for Anti-Infective Research and Development, Hartford Hospitalgrid.277313.3, Hartford, Connecticut, USA.
Antimicrob Agents Chemother ; 65(10): e0127421, 2021 09 17.
Article en En | MEDLINE | ID: mdl-34310206
ABSTRACT
In vitro MICs and in vivo pharmacodynamics of ceftazidime and cefepime human-simulated regimens (HSR) against modified carbapenem inactivation method (mCIM)-positive Pseudomonas aeruginosa isolates harboring different OXA-10-like subtypes were described. The murine thigh model assessed ceftazidime (2 g every 8 h [q8h] HSR) and cefepime (2 g and 1 g q8h HSR). Phenotypes were similar despite possessing OXA-10-like subtypes with differing spectra. Ceftazidime produced ≥1-log10 killing in all isolates. Cefepime activity was dose dependent and MIC driven. This approach may be useful in assessing the implications of ß-lactamase variants.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Infecciones por Pseudomonas Límite: Animals / Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Infecciones por Pseudomonas Límite: Animals / Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos