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Discovery of 4-benzyloxy and 4-(2-phenylethoxy) chalcone fibrate hybrids as novel PPARα agonists with anti-hyperlipidemic and antioxidant activities: Design, synthesis and in vitro/in vivo biological evaluation.
Hassan, Rasha M; Aboutabl, Mona E; Bozzi, Manuela; El-Behairy, Mohammed F; El Kerdawy, Ahmed M; Sampaolese, Beatrice; Desiderio, Claudia; Vincenzoni, Federica; Sciandra, Francesca; Ghannam, Iman A Y.
Afiliación
  • Hassan RM; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt.
  • Aboutabl ME; Medicinal and Pharmaceutical Chemistry Department (Pharmacology Group), Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), 33 El Bohouth St., P.O. 12622, Dokki, Giza, Egypt.
  • Bozzi M; Dipartimento Universitario di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Sezione di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore di Roma, Largo F. Vito 1, 00168 Roma, Italy; Istituto di Scienze e Tecnologie Chimiche "Giulio Natta"- SCITEC (C
  • El-Behairy MF; Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Sadat City 32897, Egypt.
  • El Kerdawy AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt; Department of Pharmaceutical Chemistry, School of Pharmacy, New Giza University, Newgiza, km 22 Cairo-Alexandria Desert Road, Cairo, Egypt.
  • Sampaolese B; Istituto di Scienze e Tecnologie Chimiche "Giulio Natta"- SCITEC (CNR) Sede di Roma, Largo F. Vito 1, 00168 Roma, Italy.
  • Desiderio C; Istituto di Scienze e Tecnologie Chimiche "Giulio Natta"- SCITEC (CNR) Sede di Roma, Largo F. Vito 1, 00168 Roma, Italy.
  • Vincenzoni F; Dipartimento Universitario di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Sezione di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore di Roma, Largo F. Vito 1, 00168 Roma, Italy; Fondazione Policlinico Universitario "A. Gemelli", IRCCS, Largo A.
  • Sciandra F; Istituto di Scienze e Tecnologie Chimiche "Giulio Natta"- SCITEC (CNR) Sede di Roma, Largo F. Vito 1, 00168 Roma, Italy. Electronic address: francesca.sciandra@cnr.it.
  • Ghannam IAY; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12622, Egypt. Electronic address: iman.youssef.ghannam@gmail.com.
Bioorg Chem ; 115: 105170, 2021 10.
Article en En | MEDLINE | ID: mdl-34332233
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Diseño de Fármacos / Chalconas / PPAR alfa / Ácidos Fíbricos / Hipolipemiantes / Antioxidantes Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Bioorg Chem Año: 2021 Tipo del documento: Article País de afiliación: Egipto
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Diseño de Fármacos / Chalconas / PPAR alfa / Ácidos Fíbricos / Hipolipemiantes / Antioxidantes Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Bioorg Chem Año: 2021 Tipo del documento: Article País de afiliación: Egipto