Assessment of peritoneal thickness using CT in relation to dialysis adequacy in peritoneal dialysis patients.
Ther Apher Dial
; 25(6): 954-961, 2021 Dec.
Article
en En
| MEDLINE
| ID: mdl-34370378
ABSTRACT
Studies assessing peritoneal thickness by CT in peritoneal dialysis (PD) patients are lacking. In this study, we aimed to investigate the association between peritoneal thickness as measured by CT and dialysis adequacy with peritoneal membrane characteristics in PD patients. Ninety-four PD patients were enrolled. Peritoneal thickness was measured by CT. Patients with and without a decrease in Kt/V of at least 0.3 over time were classified as Group 1 and Group 2, respectively. An increase of 0.1 unit of dialysate/plasma (D/P) creatinine over time were considered significant. The relationship between peritoneal membrane thickness, change in Kt/V, and peritoneal membrane characteristics were investigated. There were 31 (33.0%) patients in Group 1. The duration of PD (86.0 ± 64.1 vs. 59.6 ± 45.2 months, p 0.023), peritoneal thickness (1.02 ± 0.37 vs. 0.87 ± 0.21 mm, p 0.015), peritoneal calcification (7 [22.6%] vs. 3 [4.8%] patients, p 0.013], increased D/P creatinine ratio (14 [45.2%] vs. 14 [22.2%] patients, p 0.031) and CRP (13.9 ± 11.2 vs. 7.1 ± 4.8 mg/L, p 0.045) were significantly higher in Group 1, whereas albumin (3.6 ± 0.5 vs. 3.8 ± 0.6 g/dL, p 0.047) and parathyroid hormone (355.2 ± 260.2 vs. 532.1 ± 332.9 ng/L, p 0.015) levels were significantly lower. Peritoneal thickness was significantly correlated with duration of PD (r 0.775, p < 0.001) and CRP (r 0.282, p 0.006). Regression analysis showed that peritoneal thickness (Exp (B) [95% CI] 0.029 [0.003-0.253], p 0.001) was independent predictor of decreased Kt/V in PD patients. In conclusion, prolonged PD duration and increased peritoneal thickness are associated with a decrease in Kt/V over time. CT may be an alternative and noninvasive method instead of peritoneal biopsy for determining the structural changes of the peritoneal membrane .
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Peritoneo
/
Tomografía Computarizada por Rayos X
/
Diálisis Peritoneal
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Fallo Renal Crónico
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Ther Apher Dial
Asunto de la revista:
HEMATOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Turquía