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The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid ß fibril formation.
Pagnon de la Vega, María; Giedraitis, Vilmantas; Michno, Wojciech; Kilander, Lena; Güner, Gökhan; Zielinski, Mara; Löwenmark, Malin; Brundin, RoseMarie; Danfors, Torsten; Söderberg, Linda; Alafuzoff, Irina; Nilsson, Lars N G; Erlandsson, Anna; Willbold, Dieter; Müller, Stephan A; Schröder, Gunnar F; Hanrieder, Jörg; Lichtenthaler, Stefan F; Lannfelt, Lars; Sehlin, Dag; Ingelsson, Martin.
Afiliación
  • Pagnon de la Vega M; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, 75185 Uppsala, Sweden.
  • Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, 75185 Uppsala, Sweden.
  • Michno W; Department of Psychiatry and Neurochemistry, University of Gothenburg, 43180 Gothenburg, Sweden.
  • Kilander L; Department of Neuroscience, Physiology and Pharmacology, University College London, WC1E 6BT London, UK.
  • Güner G; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, 75185 Uppsala, Sweden.
  • Zielinski M; German Center for Neurodegenerative Diseases (DZNE) and Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, 81377 Munich, Germany.
  • Löwenmark M; Institute of Biological Information Processing, Structural Biochemistry (IBI-7) and JuStruct, Jülich Center for Structural Biology, Forschungszentrum Jülich, 52425 Jülich, Germany.
  • Brundin R; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, 75185 Uppsala, Sweden.
  • Danfors T; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, 75185 Uppsala, Sweden.
  • Söderberg L; Department of Surgical Sciences, Radiology, Uppsala University, 75185 Uppsala, Sweden.
  • Alafuzoff I; BioArctic AB, 11251 Stockholm, Sweden.
  • Nilsson LNG; Department of Immunology, Genetics and Pathology, Clinical and Experimental Pathology, Uppsala University, 75185 Uppsala, Sweden.
  • Erlandsson A; Department of Pharmacology, University of Oslo and Oslo University Hospital, 0316 Oslo, Norway.
  • Willbold D; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, 75185 Uppsala, Sweden.
  • Müller SA; Institute of Biological Information Processing, Structural Biochemistry (IBI-7) and JuStruct, Jülich Center for Structural Biology, Forschungszentrum Jülich, 52425 Jülich, Germany.
  • Schröder GF; Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.
  • Hanrieder J; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, State University, 141701 Dolgoprudny, Russia.
  • Lichtenthaler SF; German Center for Neurodegenerative Diseases (DZNE) and Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, 81377 Munich, Germany.
  • Lannfelt L; Institute of Biological Information Processing, Structural Biochemistry (IBI-7) and JuStruct, Jülich Center for Structural Biology, Forschungszentrum Jülich, 52425 Jülich, Germany.
  • Sehlin D; Physics Department, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.
  • Ingelsson M; Department of Psychiatry and Neurochemistry, University of Gothenburg, 43180 Gothenburg, Sweden.
Sci Transl Med ; 13(606)2021 08 11.
Article en En | MEDLINE | ID: mdl-34380771
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Péptidos beta-Amiloides / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Suecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Péptidos beta-Amiloides / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Suecia