Testicular Microvascular Flow Is Altered in Klinefelter Syndrome and Predicts Circulating Testosterone.
J Clin Endocrinol Metab
; 107(1): e236-e245, 2022 01 01.
Article
en En
| MEDLINE
| ID: mdl-34407199
ABSTRACT
CONTEXT Experimental studies on Klinefelter syndrome (KS) reported increased intratesticular testosterone (T) levels coexisting with reduced circulating levels. Abnormalities in testicular microcirculation have been claimed; however, no studies investigated in vivo testicular blood flow dynamics in humans with KS. OBJECTIVE:
To analyze the testicular microcirculation in KS by contrast-enhanced ultrasonography (CEUS) and correlate vascular parameters with endocrine function. DESIGN ANDSETTING:
Prospective study. University setting. PATIENTS Sixty-eight testicular scans, 34 testes from 19 T-naïve subjects with KS and 34 testes from age-matched eugonadal men (control) who underwent CEUS for incidental nonpalpable testicular lesions. MAINOUTCOMES:
CEUS kinetic parameters.RESULTS:
CEUS revealed slower testicular perfusion kinetics in subjects with KS than in age-matched controls. Specifically, the wash-in time (Pâ =â 0.018), mean transit time (Pâ =â 0.035), time to peak (Pâ <â 0.001), and wash-out time (Pâ =â 0.004) were all prolonged. Faster testicular blood flow was associated with higher total T levels. Principal component analysis and multiple linear regression analyses confirmed the findings and supported a role for reduced venous blood flow as independent predictor of total T levels.CONCLUSIONS:
Testicular venous blood flow is altered in KS and independently predicts T peripheral release.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Espermatogénesis
/
Testículo
/
Testosterona
/
Azoospermia
/
Hipogonadismo
/
Síndrome de Klinefelter
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Endocrinol Metab
Año:
2022
Tipo del documento:
Article
País de afiliación:
Italia