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MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer.
Kalogirou, C; Linxweiler, J; Schmucker, P; Snaebjornsson, M T; Schmitz, W; Wach, S; Krebs, M; Hartmann, E; Puhr, M; Müller, A; Spahn, M; Seitz, A K; Frank, T; Marouf, H; Büchel, G; Eckstein, M; Kübler, H; Eilers, M; Saar, M; Junker, K; Röhrig, F; Kneitz, B; Rosenfeldt, M T; Schulze, A.
Afiliación
  • Kalogirou C; Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Würzburg, Germany.
  • Linxweiler J; Department of Urology and Paediatric Urology, University Hospital Würzburg, Würzburg, Germany.
  • Schmucker P; Department of Urology, Saarland University, Homburg/Saar, Germany.
  • Snaebjornsson MT; Department of Urology and Paediatric Urology, University Hospital Würzburg, Würzburg, Germany.
  • Schmitz W; German Cancer Research Center, Division of Tumor Metabolism and Microenvironment, Heidelberg, Germany.
  • Wach S; Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Würzburg, Germany.
  • Krebs M; Department of Urology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
  • Hartmann E; Department of Urology and Paediatric Urology, University Hospital Würzburg, Würzburg, Germany.
  • Puhr M; Institute of Pathology, Julius Maximilians University and Comprehensive Cancer Center (CCC) Mainfranken, Würzburg, Germany.
  • Müller A; Department of Urology, Medical University of Innsbruck, Innsbruck, Austria.
  • Spahn M; Clinic for Diagnostic and Interventional Radiology, Saarland University, Homburg/Saar, Germany.
  • Seitz AK; Center for Urology, Hirslanden Private Hospital Group, Zurich, Switzerland.
  • Frank T; Department of Urology and Paediatric Urology, University Hospital Würzburg, Würzburg, Germany.
  • Marouf H; Department of Urology and Paediatric Urology, University Hospital Würzburg, Würzburg, Germany.
  • Büchel G; Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Würzburg, Germany.
  • Eckstein M; Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Würzburg, Germany.
  • Kübler H; Mildred Scheel Early Career Center, University Hospital Würzburg, Würzburg, Germany.
  • Eilers M; Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
  • Saar M; Department of Urology and Paediatric Urology, University Hospital Würzburg, Würzburg, Germany.
  • Junker K; Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Würzburg, Germany.
  • Röhrig F; Department of Urology, Saarland University, Homburg/Saar, Germany.
  • Kneitz B; Department of Urology, Saarland University, Homburg/Saar, Germany.
  • Rosenfeldt MT; Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Würzburg, Germany.
  • Schulze A; Department of Urology and Paediatric Urology, University Hospital Würzburg, Würzburg, Germany.
Nat Commun ; 12(1): 5066, 2021 08 20.
Article en En | MEDLINE | ID: mdl-34417456
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Regulación hacia Abajo / Regulación Neoplásica de la Expresión Génica / Colesterol / MicroARNs / Escualeno-Monooxigenasa Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged80 Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Regulación hacia Abajo / Regulación Neoplásica de la Expresión Génica / Colesterol / MicroARNs / Escualeno-Monooxigenasa Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged80 Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Alemania