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Dysconnectivity of a brain functional network was associated with blood inflammatory markers in depression.
Aruldass, Athina R; Kitzbichler, Manfred G; Morgan, Sarah E; Lim, Sol; Lynall, Mary-Ellen; Turner, Lorinda; Vertes, Petra; Cavanagh, Jonathan; Cowen, Phil; Pariante, Carmine M; Harrison, Neil A; Bullmore, Edward T.
Afiliación
  • Aruldass AR; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK. Electronic address: ara49@cam.ac.uk.
  • Kitzbichler MG; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK.
  • Morgan SE; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK.
  • Lim S; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK.
  • Lynall ME; Department of Medicine, University of Cambridge, UK.
  • Turner L; Department of Medicine, University of Cambridge, UK.
  • Vertes P; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK.
  • Cavanagh J; Centre for Immunobiology, University of Glasgow and Sackler Institute of Psychobiological Research, Queen Elizabeth University Hospital, Glasgow, UK.
  • Cowen P; University of Oxford Department of Psychiatry, Warneford Hospital, Oxford, UK.
  • Pariante CM; Stress, Psychiatry and Immunology Laboratory & Perinatal Psychiatry, Maurice Wohl Clinical Neuroscience Institute, Kings College London, UK.
  • Harrison NA; Cardiff University Brain Research Imaging Centre, Cardiff University, Maindy Road, Cardiff, UK.
  • Bullmore ET; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK.
Brain Behav Immun ; 98: 299-309, 2021 11.
Article en En | MEDLINE | ID: mdl-34450247
ABSTRACT

OBJECTIVE:

There is increasing evidence for a subgroup of major depressive disorder (MDD) associated with heightened peripheral blood inflammatory markers. In this study, we aimed to understand the mechanistic brain-immune axis in inflammation-linked depression by investigating associations between functional connectivity (FC) of brain networks and peripheral blood immune markers in depression.

METHODS:

Resting-state functional magnetic resonance imaging (fMRI) and peripheral blood inflammatory markers (C-reactive protein; CRP, interleukin-6; IL-6 and immune cells) were collected on N = 46 healthy controls (HC; CRP ≤ 3 mg/L) and N = 83 cases of depression, stratified further into low CRP cases (loCRP cases; ≤ 3 mg/L; N = 50) and high CRP cases (hiCRP cases; > 3 mg/L; N = 33). In a two-part analysis, network-based statistics (NBS) was firstly used to ascertain whole-brain FC differences in HC vs hiCRP cases. Secondly, we investigated the association between this network of interconnected brain regions and continuous measures of peripheral CRP (N = 83), IL-6 (N = 72), neutrophils and CD4+ T-cells (N = 36) in depression cases only.

RESULTS:

Case-control NBS testing revealed a single network of abnormally attenuated FC in the high CRP depression cases compared to healthy controls. Connections within this network were mainly between brain regions located in the left insula/frontal operculum and posterior cingulate cortex, which were assigned to ventral attention and default mode canonical fMRI networks respectively. Within-group analysis across all depression cases, secondarily demonstrated that FC within the identified network significantly negatively scaled with CRP, IL-6 and neutrophils.

CONCLUSIONS:

The findings suggest that inflammation is associated with disruption of functional connectivity within a brain network deemed critical for interoceptive signalling, e.g. accurate communication of peripheral bodily signals such as immune states to the brain, with implications for the pathogenesis of inflammation-linked depression.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trastorno Depresivo Mayor Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Brain Behav Immun Asunto de la revista: ALERGIA E IMUNOLOGIA / CEREBRO / PSICOFISIOLOGIA Año: 2021 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trastorno Depresivo Mayor Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Brain Behav Immun Asunto de la revista: ALERGIA E IMUNOLOGIA / CEREBRO / PSICOFISIOLOGIA Año: 2021 Tipo del documento: Article