A complete proton and carbon-13 NMR analysis of fluocinonide, a fluorinated corticosteroid.
Steroids
; 48(3-4): 267-77, 1986.
Article
en En
| MEDLINE
| ID: mdl-3445282
ABSTRACT
This paper presents a complete analysis of the proton and carbon-13 NMR spectra of 21-acetoxy-6 alpha,9-difluoro-11 beta-hydroxy-16 alpha,17-(1-methylethylidene) bis-(oxy) pregna-1,4-diene-3,20-dione, a potent anti-inflammatory fluorosteroid. The 300 MHz proton spectrum was analyzed using a combination of the two-dimensional homonuclear chemical shift correlation (COSY) technique and one-dimensional NOE difference spectra. Exact coupling constants and chemical shifts were obtained by spectral simulation and iteration. The carbon-13 spectrum was assigned from the proton spectrum via a two-dimensional heteronuclear chemical shift experiment, and long-range fluorine-proton couplings were confirmed by a fully coupled heteronuclear COSY-type experiment.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fluocinolona Acetonida
/
Fluocinonida
/
Espectroscopía de Resonancia Magnética
Idioma:
En
Revista:
Steroids
Año:
1986
Tipo del documento:
Article
País de afiliación:
Canadá