Single-cell omics: Overview, analysis, and application in biomedical science.
J Cell Biochem
; 122(11): 1571-1578, 2021 11.
Article
en En
| MEDLINE
| ID: mdl-34459502
ABSTRACT
Single-cell sequencing methods provide the highest resolution insight into cellular heterogeneity. Owing to their rapid growth and decreasing cost, they are now widely accessible to scientists worldwide. Single-cell technologies enable analysis of a large number of cells, making them powerful tools to characterise rare cell types and refine our understanding of diverse cell states. Moreover, single-cell application in biomedical sciences helps to unravel mechanisms related to disease pathogenesis and outcome. In this Viewpoint, we briefly describe existing single-cell methods (genomics, transcriptomics, epigenomics, proteomics, and mulitomics), comment on available analysis tools, and give examples of method applications in the biomedical field.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Biología Computacional
/
Perfilación de la Expresión Génica
/
Proteómica
/
Análisis de la Célula Individual
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Cell Biochem
Año:
2021
Tipo del documento:
Article
País de afiliación:
Alemania