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Novel 1,5-diaryl pyrazole-3-carboxamides as selective COX-2/sEH inhibitors with analgesic, anti-inflammatory, and lower cardiotoxicity effects.
Hendawy, O M; Gomaa, Hesham A M; Alzarea, Sami I; Alshammari, Mutariah S; Mohamed, Fatma A M; Mostafa, Yaser A; Abdelazeem, Ahmed H; Abdelrahman, Mostafa H; Trembleau, Laurent; Youssif, Bahaa G M.
Afiliación
  • Hendawy OM; Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia; Department of Clinical Pharmacology, Faculty of Medicine, Beni-Suef University, Egypt.
  • Gomaa HAM; Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia.
  • Alzarea SI; Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia.
  • Alshammari MS; Department of Chemistry, College of Science, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia.
  • Mohamed FAM; Clinical Laboratory Science Department, College of Applied Medical Sciences, Jouf University, Aljouf 72341, Saudi Arabia; Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21321, Egypt.
  • Mostafa YA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
  • Abdelazeem AH; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt; Department of Pharmaceutical Sciences, College of Pharmacy, Riyadh Elm University, Riyadh 11681, Saudi Arabia.
  • Abdelrahman MH; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.
  • Trembleau L; School of Natural and Computing Sciences, University of Aberdeen, Meston Building, Aberdeen AB24 3UE, United Kingdom. Electronic address: l.trembleau@abdn.ac.uk.
  • Youssif BGM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address: bahaa.youssif@pharm.aun.edu.eg.
Bioorg Chem ; 116: 105302, 2021 11.
Article en En | MEDLINE | ID: mdl-34464816
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Cardiotónicos / Antiinflamatorios no Esteroideos / Inhibidores Enzimáticos / Analgésicos Límite: Animals / Humans Idioma: En Revista: Bioorg Chem Año: 2021 Tipo del documento: Article País de afiliación: Egipto
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Cardiotónicos / Antiinflamatorios no Esteroideos / Inhibidores Enzimáticos / Analgésicos Límite: Animals / Humans Idioma: En Revista: Bioorg Chem Año: 2021 Tipo del documento: Article País de afiliación: Egipto